ArticleInternational journal of clinical and experimental medicine2015
Impact of sleeve gastrectomy verses sleeve gastrectomy plus side-to-side jejunoileal anastomosis on weight loss and metabolic control in an obese rat model.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors at 2 institutions in 1 country.
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Abstract
aimTo study the impact of sleeve gastrectomy plus side-to-side jejunoileal anastomosis on weight loss and the remission of type 2 diabetes mellitus.
methodsThirty-three 7 weeks old male Zucker diabetic fatty rats were randomized into three groups: sleeve gastrectomy plus side-to-side jejunoileal anastomosis (JI-SG group), sleeve gastrectomy (SG group), sham surgery (Control group).
resultsThe weight of rats in JI-SG group and SG group was significantly lower than control group at 2 weeks postoperatively, and body weight in JI-SG group was lower than SG group since 4 week postoperatively. The blood Glucose was significantly improved for both JI-SG group and SG group, and increased in Control group at 2 weeks after surgery. The serum ghrelin level of rats in JI-SG, SG group was significantly decreased, but without difference between two groups; compared with that preoperatively, the GLP-1 level of rats in JI-SG group was significantly higher at 12 weeks postoperatively; SG group and SO group had no difference in the GLP-1. The serum insulin level in rats was also decreased in JI-SG group and SG group at 6 weeks postoperatively, and plasma insulin level in JI-SG group was significantly lower than those in the SG group at 12 weeks postoperatively.
conclusionsJI-SG is superior to SG as the treatment of type 2 diabetes mellitus and weight control in obese diabetic rodents.
Indexed as
Identifiers
26064251PMC4443085W2399856208What OpenQuestion holds
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