ArticleInternational journal of clinical and experimental medicine2015
Negative pressure wound therapy accelerates rats diabetic wound by promoting agenesis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Negative pressure wound therapy in the treatment of diabetic foot ulcers may be mediated through differential gene expression.Acta diabetologica · 2019Trial
- Negative Pressure Wound Therapy with Instillation: Analysis of the Rinsing Fluid as a Monitoring Tool and Approach to the Inflammatory Process: A Pilot Study.Journal of clinical medicine · 2023Article
- Article
- [National expert consensus on the application of negative pressure wound therapy in the treatment of diabetic foot wounds (2021 version)].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Consensus on the application of negative pressure wound therapy of diabetic foot wounds.Burns & trauma · 2021Review
- The successful management for long-term intractable enteroatmospheric fistula: A case report.Annals of medicine and surgery (2012) · 2020Article
- MicroRNA-126: a promising biomarker for angiogenesis of diabetic wounds treated with negative pressure wound therapy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- The effect of a novel minimally invasive strategy for infected necrotizing pancreatitis.Surgical endoscopy · 2017Article
- Negative pressure wound therapy: Regulating blood flow perfusion and microvessel maturation through microvascular pericytes.International journal of molecular medicine · 2017Article
- Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Prognostic Factors for Enteroatmospheric Fistula in Open Abdomen Treated with Negative Pressure Wound Therapy: a Multicentre Experience.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- [Research progress on the animal models and treatment strategies of diabetic foot ulcer].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017Review
- Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis.Experimental and therapeutic medicine · 2016Article
- Use of Ozone to Treat Ileostomy Dermatitis in an Experimental Rat Model.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative Pressure Wound Therapy (NPWT) has become widely adopted to several wound treatment over the last 15 years, including diabetic foot ulcer (DFU). Much of the existing evidence supports that NPWT increase in blood flow, reduce in edema, decrease bacterial proliferation and accelerate granulation-tissue formation. However, the accurate mechanism is not clear till now. The aim of the present study was to further elucidate the effects of NPWT on angiogenesis of diabetic wound model. As result, our data showed: 1) NPWT promoted the wound healing and blood perfusion on both diabetic and normal wound compared with control, 2) The NPWT increased wound vessel density, and the wound treated with NPWT showed well developed and more functional vessels at day 7 post operation compared with control 3) NPWT up regulated the expression of VEGF at day 3 and Ang1 at day 7 on RNA and protein level. 4) Ang2 was up regulated in diabetic rats but NPWT attenuated this affection. Our data indicated that NPWT increased vessel density and promoted the maturation of neovascular over the potential mechanism of up regulated VEGF and Ang1 and down regulated of Ang2.
Indexed as
Identifiers
26064242PMC4443076W2401475341What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.