Evidence map›Paper›PMID 26064157›Full record

ReviewEvidence-based complementary and alternative medicine : eCAM2015

Complementary and Alternative Therapies for Autism Spectrum Disorder.

Natascia Brondino, Laura Fusar-Poli, Matteo Rocchetti, Umberto Provenzani, Francesco Barale, Pierluigi Politi

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05218577 (The Effect of High Selenium Functional Food and Selenium Supplement on Developmental Level in Autism Spectrum Disorder), which is not on this map. Cited by 39 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 7 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05218577 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of High Selenium Functional Food and Selenium Supplement on Developmental Level in Autism Spectrum Disorder

TypeinterventionalSponsorNeny TrianaRan2021 to 2021Enrolled65ConditionsAutism Spectrum DisorderArmshigh selenium functional food, selenium supplement, Placebo
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Complementary and Alternative Medicine for Autism - A Systematic Review.Journal of autism and developmental disorders · 2025
    Pooled it
  2. Pooled it
  3. Music therapy for autistic people.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Article
  14. A Meta-analysis of Randomized Placebo-controlled Trials on the Effects of Probiotics for Autism Spectrum Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Natascia BrondinoDepartment of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.ORCID 0000-0002-3128-1592
Laura Fusar-PoliDepartment of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
Matteo RocchettiDepartment of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
Umberto ProvenzaniDepartment of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
Francesco BaraleDepartment of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
Pierluigi PolitiDepartment of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.ORCID 0000-0002-4602-2032
University of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Complementary and alternative medicine (CAM) represents a popular therapeutic option for patients with autism spectrum disorder (ASD). Unfortunately, there is a paucity of data regarding the efficacy of CAM in ASD. The aim of the present systematic review is to investigate trials of CAM in ASD. Material and Methods. We searched the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, CINAHL, Psychology and Behavioral Sciences Collection, Agricola, and Food Science Source. Results. Our literature search identified 2687 clinical publications. After the title/abstract screening, 139 publications were obtained for detailed evaluation. After detailed evaluation 67 studies were included, from hand search of references we retrieved 13 additional studies for a total of 80. Conclusion. There is no conclusive evidence supporting the efficacy of CAM therapies in ASD. Promising results are reported for music therapy, sensory integration therapy, acupuncture, and massage.

Identifiers

PMID26064157
PMCPMC4439475
OpenAlexW1518643840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.