Evidence map›Paper›PMID 26064104›Full record

ArticleAdvances in pharmacological sciences2015

Antileishmanial Effect of 5,3'-Hydroxy-7,4'-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies.

Sara M Robledo, Wilson Cardona, Karen Ligardo, Jéssica Henao, Natalia Arbeláez, Andrés Montoya, Fernando Alzate, Juan M Pérez, Victor Arango, Iván D Vélez and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in pharmacological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sara M RobledoPECET, Medical Research Institute, School of Medicine, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Wilson CardonaChemistry of Colombian Plants, Institute of Chemistry, Exact and Natural Sciences School, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Karen LigardoPECET, Medical Research Institute, School of Medicine, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Jéssica HenaoPECET, Medical Research Institute, School of Medicine, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Natalia ArbeláezPECET, Medical Research Institute, School of Medicine, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Andrés MontoyaPECET, Medical Research Institute, School of Medicine, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Fernando AlzateBotanical Studies, Institute of Biology, Exact and Natural Sciences School, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Juan M PérezChemistry of Colombian Plants, Institute of Chemistry, Exact and Natural Sciences School, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Victor ArangoPharmacy School, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Iván D VélezPECET, Medical Research Institute, School of Medicine, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Jairo SáezChemistry of Colombian Plants, Institute of Chemistry, Exact and Natural Sciences School, University of Antioquia (UdeA), Calle 70, No. 52-21, A.A. 1226, Medellín, Colombia.
Universidad de Antioquia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Species of Picramnia genus are used in folk medicine to treat or prevent skin disorders, but only few species have been studied for biological activity and chemical composition. P. gracilis Tul. is a native species from Central and South America and although its fruits are edible, phytochemical analysis or medicinal uses of this species are not known. In the search of candidates to antileishmanial drugs, this work aimed to evaluate the antileishmanial activity of P. gracilis Tul. in in vitro and in vivo studies. Only ethanolic extract of fruits showed leishmanicidal activity. The majoritarian metabolite was 5,3'-hydroxy-7,4'-dimethoxyflavanone ether that exhibited high activity against L. (V.) panamensis (EC50 17.0 + 2.8 mg/mL, 53.7 μM) and low toxicity on mammalian U-937 cells, with an index of selectivity >11.8. In vivo studies showed that the flavanone administered in solution (2 mg/kg/day) or cream (2%) induces clinical improvement and no toxicity in hamsters with CL. In conclusion, this is the first report about isolation of 5,3'-hydroxy-7,4'-dimethoxyflavanone of P. gracilis Tul. The leishmanicidal activity attributed to this flavanone is also reported for the first time. Finally, the in vitro and in vivo leishmanicidal activity reported here for 5,3'-hydroxy-7,4'-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development.

Identifiers

PMID26064104
PMCPMC4430626
OpenAlexW2076410051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.