ReviewGastroenterology research and practice2015
Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.
Review in Gastroenterology research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review.Nutrients · 2021Pooled it
- Proton Pump Inhibitor-Associated Hypomagnesemia: A Case Report Highlighting a Rare Adverse Effect.Cureus · 2026Article
- Case report: delayed profound hypomagnesemia from carboplatin- associated renal magnesium wasting.BMC nephrology · 2026Article
- Current Medical Controversies in Zollinger-Ellison Syndrome.Biomedicines · 2025Review
- Effect of Histamine-2 Receptor Antagonists on Hypocalcemia after Thyroidectomy: A Retrospective Cohort Study and Sensitivity Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Cerebellar Syndrome From Proton Pump Inhibitor-Induced Hypomagnesemia: Two Reversible but Relapsing Cases.Case reports in otolaryngology · 2025Article
- Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density.Future science OA · 2024Article
- Proton-pump inhibitor use amongst patients with severe hypomagnesemia.Frontiers in pharmacology · 2023Article
- Pharmacotherapy Problems in Best Possible Medication History of Hospital Admission in the Elderly.Pharmacy (Basel, Switzerland) · 2022Article
- Severe Electrolyte Disturbances Due to Proton Pump Inhibitor Therapy: An Underrecognized Problem with Potentially Severe Sequelae.The American journal of case reports · 2022Article
- The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases.Biological trace element research · 2021Review
- Seizure and delirium secondary to carboplatin and pantoprazole therapy-induced hypomagnesemia in a cancer patient.Clinical case reports · 2021Article
- Overtesting and overtreatment-statement from the European Academy of Paediatrics (EAP).European journal of pediatrics · 2019Article
- Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.International journal of molecular sciences · 2019Review
- Association of hypomagnesemia with cardiovascular diseases and hypertension.International Journal of Cardiology. Hypertension · 2019Review
- Extreme hypomagnesemia: characteristics of 119 consecutive inpatients.Internal and emergency medicine · 2018Observational
- A survey of medicine use in children and adolescents in Austria.European journal of pediatrics · 2018Article
- [Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].Der Internist · 2018Review
- [Refeeding syndrome in geriatric patients : A frequently overlooked complication].Zeitschrift fur Gerontologie und Geriatrie · 2018Review
- Proton pump inhibitor-associated hypomagnesaemia and hypocalcaemia.Australian prescriber · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2006, hypomagnesemia was first described as a complication of proton-pump inhibitors. To address this issue, we systematically reviewed the literature. Hypomagnesemia, mostly associated with hypocalcemic hypoparathyroidism and hypokalemia, was reported in 64 individuals on long-term proton-pump inhibitors. Hypomagnesemia recurred following replacement of one proton-pump inhibitor with another but not with a histamine type-2 receptor antagonist. The association between proton-pump inhibitors and magnesium metabolism was addressed in 14 case-control, cross-sectional studies. An association was found in 11 of them: 6 reports found that the use of proton-pump inhibitors is associated per se with a tendency towards hypomagnesemia, 2 found that this tendency is more pronounced in patients concurrently treated with diuretics, carboplatin, or cisplatin, and 2 found a relevant tendency to hypomagnesemia in patients with poor renal function. Finally, findings likely reflecting decreased intestinal magnesium uptake were observed on treatment with proton-pump inhibitors. Three studies did not disclose any relationship between magnesium metabolism and treatment with histamine type-2 receptor antagonists. In conclusion, proton-pump inhibitors may cause hypomagnesemia. In these cases, switching to a histamine type-2 receptor antagonist is advised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.