ArticleDisease markers2015
Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma.
Article in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- SKA1 plays a tumor-promoting role in colorectal cancer: coupling TAF1‑dependent transcription with RPL8 interaction.Molecular and cellular biochemistry · 2026Article
- SKA1/2/3 is a prognostic and predictive biomarker in esophageal adenocarcinoma and squamous cell carcinoma.BMC cancer · 2024Article
- Article
- SKA1 expression in oral squamous cell carcinoma and its relationship to P53 and clinicopathologic features.International journal of clinical and experimental pathology · 2020Article
- Kinetochore Recruitment of the Spindle and Kinetochore-Associated (Ska) Complex Is Regulated by Centrosomal PP2A inGenetics · 2019Article
- SKA1 promotes malignant phenotype and progression of glioma via multiple signaling pathways.Cancer cell international · 2019Article
- Article
- High expression of spindle and kinetochore- associated protein 1 predicts early recurrence and progression of non-muscle invasive bladder cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Regulation of spindle and kinetochore-associated protein 1 by antitumor miR-10a-5p in renal cell carcinoma.Cancer science · 2017Article
- Targeting mitotic pathways for endocrine-related cancer therapeutics.Endocrine-related cancer · 2017Review
- Hypoxia promotes chemotherapy resistance by down-regulating SKA1 gene expression in human osteosarcoma.Cancer biology & therapy · 2017Article
- SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer.Oncology reports · 2016Article
- Identification of HCG18 and MCM3AP-AS1 That Associate With Bone Metastasis, Poor Prognosis and Increased Abundance of M2 Macrophage Infiltration in Prostate Cancer.Technology in cancer research & treatmentArticle
- SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway.Cell cycle (Georgetown, Tex.)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSpindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development.
methodsIn this study, immunohistochemical analysis was used to determine the expression of SKA1 in papillary thyroid carcinoma (PTC) and adjacent tissues. We used quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis to further verify the results.
resultsWe found that SKA1 expression was significantly higher in PTC tissues than normal adjacent tissues (P < 0.05). There existed a significant correlation among a higher SKA1 expression, including lymphoid node (P = 0.005), clinical stage (P = 0.015), and extrathyroid invasion (P = 0.004). Survival analysis showed high SKA1 expression in PTC patients more likely to relapse after surgery.
conclusionHigh SKA1 expression is predictive of poor prognosis of PTC, implying that SKA1 may be a promising new target for targeted therapies for PTC.
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