ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
The phase difference between neural drives to antagonist muscles in essential tremor is associated with the relative strength of supraspinal and afferent input.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Acute effects of caffeine or quercetin ingestion on motor unit firing pattern before and after resistance exercise.European journal of applied physiology · 2024Trial
- Sensing and decoding the neural drive to paralyzed muscles during attempted movements of a person with tetraplegia using a sleeve array.Journal of neurophysiology · 2021Trial
- Effect of milk fat globule membrane supplementation on motor unit adaptation following resistance training in older adults.Physiological reports · 2020Trial
- An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor.Neuromodulation : journal of the International Neuromodulation Society · 2019Trial
- Defining the Rhythm: Developing a New Method to Describe Tremor and Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Ultrasound Imaging Triggered Tremor Suppression With Personalized Afferent Stimulation Frequency.IEEE transactions on bio-medical engineering · 2025Article
- Simple biomarkers to distinguish Parkinson's disease from its mimics in clinical practice: a comprehensive review and future directions.Frontiers in neurology · 2024Review
- Towards Ultrasound Imaging-based Closed-loop Peripheral Nerve Stimulation for Tremor Suppression.Current opinion in biomedical engineering · 2023Article
- The dose-response relationship of quercetin on the motor unit firing patterns and contractile properties of muscle in men and women.Journal of the International Society of Sports Nutrition · 2023Article
- Decoding firings of a large population of human motor units from high-density surface electromyogram in response to transcranial magnetic stimulation.The Journal of physiology · 2023Article
- Essential Tremor accentuates the pattern of tremor-band coherence between upper-limb muscles.Journal of neurophysiology · 2023Article
- Translation of surface electromyography to clinical and motor rehabilitation applications: The need for new clinical figures.Translational neuroscience · 2023Article
- Distribution of tremorogenic activity among the major superficial muscles of the upper limb in persons with Essential tremor.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Neuromuscular characteristics of front and back legs in junior fencers.Experimental brain research · 2022Article
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Quercetin ingestion modifies human motor unit firing patterns and muscle contractile properties.Experimental brain research · 2021Article
- Peripheral electrical stimulation to reduce pathological tremor: a review.Journal of neuroengineering and rehabilitation · 2021Review
- A Review on Wearable Technologies for Tremor Suppression.Frontiers in neurology · 2021Review
- Spinal motoneurons of the human newborn are highly synchronized during leg movements.Science advances · 2020Article
- Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of essential tremor (ET), the most common movement disorder, is not fully understood. We investigated which factors determine the variability in the phase difference between neural drives to antagonist muscles, a long-standing observation yet unexplained. We used a computational model to simulate the effects of different levels of voluntary and tremulous synaptic input to antagonistic motoneuron pools on the tremor. We compared these simulations to data from 11 human ET patients. In both analyses, the neural drive to muscle was represented as the pooled spike trains of several motor units, which provides an accurate representation of the common synaptic input to motoneurons. The simulations showed that, for each voluntary input level, the phase difference between neural drives to antagonist muscles is determined by the relative strength of the supraspinal tremor input to the motoneuron pools. In addition, when the supraspinal tremor input to one muscle was weak or absent, Ia afferents provided significant common tremor input due to passive stretch. The simulations predicted that without a voluntary drive (rest tremor) the neural drives would be more likely in phase, while a concurrent voluntary input (postural tremor) would lead more frequently to an out-of-phase pattern. The experimental results matched these predictions, showing a significant change in phase difference between postural and rest tremor. They also indicated that the common tremor input is always shared by the antagonistic motoneuron pools, in agreement with the simulations. Our results highlight that the interplay between supraspinal input and spinal afferents is relevant for tremor generation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.