ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Differential patterns of amygdala and ventral striatum activation predict gender-specific changes in sexual risk behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Female Affective Perception of Mainstream and Paraphilic Pornography: Associations with Sexual and Psychological Intrapersonal Variables.Archives of sexual behavior · 2024Article
- Risky decision-making strategies mediate the relationship between amygdala activity and real-world financial savings among individuals from lower income households: A pilot study.Behavioural brain research · 2022Article
- An empirical study of affective and cognitive functions in Compulsive Sexual Behavior Disorder.Journal of behavioral addictions · 2021Article
- Socio-demographic and social support factors related to substance use in South African in-school adolescents: Insights from the Girls Achieve Power (GAP Year) trial in three peri-urban settings.Gates open research · 2021Article
- Women at Greater Sexual Risk for STIs/HIV Have a Lower Mesolimbic and Affective Bias Response to Sexual Stimuli.Frontiers in behavioral neuroscience · 2019Article
- Prefrontal Executive Control Rescues Risk for Anxiety Associated with High Threat and Low Reward Brain Function.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Sexual risk-taking and subcortical brain volume in adolescence.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Article
- Reward-Related Ventral Striatum Activity Buffers against the Experience of Depressive Symptoms Associated with Sleep Disturbances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Heightened activity in social reward networks is associated with adolescents' risky sexual behaviors.Developmental cognitive neuroscience · 2017Article
- A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior.Translational psychiatry · 2017Article
- Brain Imaging of Human Sexual Response: Recent Developments and Future Directions.Current sexual health reports · 2017Review
- Adolescent cannabis use and repeated voluntary unprotected sex in women.Addiction (Abingdon, England) · 2016Article
- An fMRI Study of Responses to Sexual Stimuli as a Function of Gender and Sensation Seeking: A Preliminary Analysis.Journal of sex research · 2016Article
- Paroxetine Treatment of Problematic Pornography Use: A Case Series.Journal of behavioral addictions · 2016Article
- Risk Perception and Risk-Taking Behaviour during Adolescence: The Influence of Personality and Gender.PloS one · 2016Article
- Sex, Impulsivity, and Anxiety: Interplay between Ventral Striatum and Amygdala Reactivity in Sexual Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Abstract
Although the initiation of sexual behavior is common among adolescents and young adults, some individuals express this behavior in a manner that significantly increases their risk for negative outcomes including sexually transmitted infections. Based on accumulating evidence, we have hypothesized that increased sexual risk behavior reflects, in part, an imbalance between neural circuits mediating approach and avoidance in particular as manifest by relatively increased ventral striatum (VS) activity and relatively decreased amygdala activity. Here, we test our hypothesis using data from seventy 18- to 22-year-old university students participating in the Duke Neurogenetics Study. We found a significant three-way interaction between amygdala activation, VS activation, and gender predicting changes in the number of sexual partners over time. Although relatively increased VS activation predicted greater increases in sexual partners for both men and women, the effect in men was contingent on the presence of relatively decreased amygdala activation and the effect in women was contingent on the presence of relatively increased amygdala activation. These findings suggest unique gender differences in how complex interactions between neural circuit function contributing to approach and avoidance may be expressed as sexual risk behavior in young adults. As such, our findings have the potential to inform the development of novel, gender-specific strategies that may be more effective at curtailing sexual risk behavior.
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