ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Linkage analysis in a Dutch population isolate shows no major gene for left-handedness or atypical language lateralization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Handedness in twins: meta-analyses.BMC psychology · 2022Pooled it
- Genome-wide association study identifies 48 common genetic variants associated with handedness.Nature human behaviour · 2021Pooled it
- Exome-wide analysis implicates rare protein-altering variants in human handedness.Nature communications · 2024Article
- Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex.eLife · 2023Article
- Molecular and cellular determinants of motor asymmetry in zebrafish.Nature communications · 2020Article
- Genome sequencing for rightward hemispheric language dominance.Genes, brain, and behavior · 2019Article
- The molecular genetics of hand preference revisited.Scientific reports · 2019Article
- DNA methylation of dopamine-related gene promoters is associated with line bisection deviation in healthy adults.Scientific reports · 2019Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
- Heritability of language laterality assessed by functional transcranial Doppler ultrasound: a twin study.Wellcome open research · 2019Article
- Resounding failure to replicate links between developmental language disorder and cerebral lateralisation.PeerJ · 2018Article
- Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys.Brain structure & function · 2017Article
- Article
- Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries.eLife · 2017Article
- Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults.Molecular neurobiology · 2016Article
- The Contribution of the Corpus Callosum to Language Lateralization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
9 authors.
Funding
Abstract
Cerebral dominance of language function and hand preference are suggested to be heritable traits with possible shared genetic background. However, joined genetic studies of these traits have never been conducted. We performed a genetic linkage study in 37 multigenerational human pedigrees of both sexes (consisting of 355 subjects) enriched with left-handedness in which we also measured language lateralization. Hand preference was measured with the Edinburgh Handedness Inventory, and language lateralization was measured with functional transcranial Doppler during language production. The estimated heritability of left-handedness and language lateralization in these pedigrees is 0.24 and 0.31, respectively. A parametric major gene model was tested for left-handedness. Nonparametric analyses were performed for left-handedness, atypical lateralization, and degree of language lateralization. We did not observe genome-wide evidence for linkage in the parametric or nonparametric analyses for any of the phenotypes tested. However, multiple regions showed suggestive evidence of linkage. The parametric model showed suggestive linkage for left-handedness in the 22q13 region [heterogeneity logarithm of odds (HLOD) = 2.18]. Nonparametric multipoint analysis of left-handedness showed suggestive linkage in the same region [logarithm of odds (LOD) = 2.80]. Atypical language lateralization showed suggestive linkage in the 7q34 region (LODMax = 2.35). For strength of language lateralization, we observed suggestive linkage in the 6p22 (LODMax = 2.54), 7q32 (LODMax = 1.93), and 9q33 (LODMax = 2.10) regions. We did not observe any overlap of suggestive genetic signal between handedness and the extent of language lateralization. The absence of significant linkage argues against the presence of a major gene coding for both traits; rather, our results are suggestive of these traits being two independent polygenic complex traits.
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