ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Molecular mechanisms controlling the migration of striatal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons.Stem cell reports · 2026Article
- Artificial Meshed Vessel-Induced Dimensional Breaking Growth of Human Brain Organoids and Multiregional Assembloids.ACS nano · 2024Article
- Developmental deficits of MGE-derived interneurons in theFrontiers in cell and developmental biology · 2023Article
- Interneuron odyssey: molecular mechanisms of tangential migration.Frontiers in neural circuits · 2023Review
- St18 specifies globus pallidus projection neuron identity in MGE lineage.Nature communications · 2022Article
- Cellular resolution anatomical and molecular atlases for prenatal human brains.The Journal of comparative neurology · 2022Article
- Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis.Stem cell reports · 2021Article
- Corpus Callosum Agenesis: An Insight into the Etiology and Spectrum of Symptoms.Brain sciences · 2020Review
- GABAergic Abnormalities Associated with Sensorimotor Cortico-striatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naïve Patients with Schizophrenia.Neuroscience bulletin · 2020Article
- Therapeutic Plasticity of Neural Stem Cells.Frontiers in neurology · 2020Review
- Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Parallel Emergence of a Compartmentalized Striatum with the Phylogenetic Development of the Cerebral Cortex.Brain sciences · 2019Review
- Human Pluripotent Stem Cell-Derived Striatal Interneurons: Differentiation and Maturation In Vitro and in the Rat Brain.Stem cell reports · 2019Article
- Transcription FactorsFrontiers in molecular neuroscience · 2019Article
- New Insights Into Cholinergic Neuron Diversity.Frontiers in molecular neuroscience · 2019Review
- Abnormalities in cortical interneuron subtypes in ephrin-B mutant mice.The European journal of neuroscience · 2018Article
- Autonomous and non-autonomous roles for ephrin-B in interneuron migration.Developmental biology · 2017Article
- Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.Scientific reports · 2017Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
In the developing telencephalon, the medial ganglionic eminence (MGE) generates many cortical and virtually all striatal interneurons. While the molecular mechanisms controlling the migration of interneurons to the cortex have been extensively studied, very little is known about the nature of the signals that guide interneurons to the striatum. Here we report that the allocation of MGE-derived interneurons in the developing striatum of the mouse relies on a combination of chemoattractive and chemorepulsive activities. Specifically, interneurons migrate toward the striatum in response to Nrg1/ErbB4 chemoattraction, and avoid migrating into the adjacent cortical territories by a repulsive activity mediated by EphB/ephrinB signaling. Our results also suggest that the responsiveness of MGE-derived striatal interneurons to these cues is at least in part controlled by the postmitotic activity of the transcription factor Nkx2-1. This study therefore reveals parallel mechanisms for the migration of MGE-derived interneurons to the striatum and the cerebral cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.