ArticleMolecular systems biology2015
Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- EmbSAM: cell boundary localization and Segment Anything Model for fast images of developing embryos.Communications biology · 2025Article
- High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations.BMC biology · 2025Article
- Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry.Nature communications · 2025Article
- Deep learning-based enhancement of fluorescence labeling for accurate cell lineage tracing during embryogenesis.Bioinformatics (Oxford, England) · 2024Article
- Modulating cell proliferation by asymmetric division: A conserved pattern in the early embryogenesis of nematode species.microPublication biology · 2024Article
- Novel metrics reveal new structure and unappreciated heterogeneity in Caenorhabditis elegans development.PLoS computational biology · 2023Article
- Delineating the mechanisms and design principles ofComputational and structural biotechnology journal · 2022Review
- Initial characterization of gap phase introduction in every cell cycle ofFrontiers in cell and developmental biology · 2022Article
- Computable early Caenorhabditis elegans embryo with a phase field model.PLoS computational biology · 2022Article
- Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation.Nature communications · 2020Article
- Multilevel regulation of muscle-specific transcription factor hlh-1 during Caenorhabditis elegans embryogenesis.Development genes and evolution · 2020Article
- Digging deeper: methodologies for high-content phenotyping in Caenorhabditis elegans.Lab animal · 2019Review
- A high-content imaging approach to profileDevelopment (Cambridge, England) · 2019Article
- Establishment of Signaling Interactions with Cellular Resolution for Every Cell Cycle of Embryogenesis.Genetics · 2018Article
- Conserved gene regulatory module specifies lateral neural borders across bilaterians.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Comparative proteome analysis between C . briggsae embryos and larvae reveals a role of chromatin modification proteins in embryonic cell division.Scientific reports · 2017Article
- Article
- Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis.The Journal of biological chemistry · 2016Article
- Combinatorial decoding of the invariant C. elegans embryonic lineage in space and time.Genesis (New York, N.Y. : 2000) · 2016Review
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18 authors.
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Abstract
Coordination of cell division timing is crucial for proper cell fate specification and tissue growth. However, the differential regulation of cell division timing across or within cell types during metazoan development remains poorly understood. To elucidate the systems-level genetic architecture coordinating division timing, we performed a high-content screening for genes whose depletion produced a significant reduction in the asynchrony of division between sister cells (ADS) compared to that of wild-type during Caenorhabditis elegans embryogenesis. We quantified division timing using 3D time-lapse imaging followed by computer-aided lineage analysis. A total of 822 genes were selected for perturbation based on their conservation and known roles in development. Surprisingly, we find that cell fate determinants are not only essential for establishing fate asymmetry, but also are imperative for setting the ADS regardless of cellular context, indicating a common genetic architecture used by both cellular processes. The fate determinants demonstrate either coupled or separate regulation between the two processes. The temporal coordination appears to facilitate cell migration during fate specification or tissue growth. Our quantitative dataset with cellular resolution provides a resource for future analyses of the genetic control of spatial and temporal coordination during metazoan development.
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