Evidence map›Paper›PMID 26063782›Full record

ArticleJournal of neurophysiology2015

Inhibitory input to the direction-selective ganglion cell is saturated at low contrast.

Mikhail Y Lipin, W Rowland Taylor, Robert G Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Spiking Characteristics of Network-Mediated Responses Arising in Direction-Selective Ganglion Cells of Rabbit and Mouse Retinas to Electric Stimulation for Retinal Prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Visual Circuits for Direction Selectivity.Annual review of neuroscience · 2017
    Review
  14. Article
  15. Article
  16. Contributions of Rod and Cone Pathways to Retinal Direction Selectivity Through Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  17. Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mikhail Y LipinDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania; and misha@retina.anatomy.upenn.edu.
W Rowland TaylorCasey Eye Institute, Oregon Health and Science University, Portland, Oregon.
Robert G SmithDepartment of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania; and.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Retinal mechanisms for direction selectivityR01EY022070 · NEI · UNIVERSITY OF PENNSYLVANIA · PI SMITH, ROBERT G, TAYLOR, WILLIAM ROWLAND · 2012 to 2019
$2.8M
Retinal circuits for precise signalingR01EY016607 · NEI · UNIVERSITY OF PENNSYLVANIA · PI SMITH, ROBERT G · 2006 to 2014
$2.7M
NEI NIH HHS EY-016607NEI NIH HHS EY-022070NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY016607NEI NIH HHS R01 EY022070
6 · The paper itself

Abstract

Direction-selective ganglion cells (DSGCs) respond selectively to motion toward a "preferred" direction, but much less to motion toward the opposite "null" direction. Directional signals in the DSGC depend on GABAergic inhibition and are observed over a wide range of speeds, which precludes motion detection based on a fixed temporal correlation. A voltage-clamp analysis, using narrow bar stimuli similar in width to the receptive field center, demonstrated that inhibition to DSGCs saturates rapidly above a threshold contrast. However, for wide bar stimuli that activate both the center and surround, inhibition depends more linearly on contrast. Excitation for both wide and narrow bars was also more linear. We propose that positive feedback, likely within the starburst amacrine cell or its network, produces steep saturation of inhibition at relatively low contrast. This mechanism renders GABA release essentially contrast and speed invariant, which enhances directional signals for small objects and thereby increases the signal-to-noise ratio for direction-selective signals in the spike train over a wide range of stimulus conditions. The steep saturation of inhibition confers to a neuron immunity to noise in its spike train, because when inhibition is strong no spikes are initiated.

Indexed as

AcetylcholineAction PotentialsAmacrine CellsAnimalsFeedback, Physiologicalgamma-Aminobutyric AcidGlutamic AcidGuinea PigsMotionNeural InhibitionPatch-Clamp TechniquesPhotic StimulationRabbitsRetinal Ganglion CellsTissue Culture TechniquesVision, OcularAcetylcholinegamma-Aminobutyric AcidGlutamic Acidideal observerneural computationnoise immunityretinal circuitrySchmitt trigger

Identifiers

PMID26063782
PMCPMC4533110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.