ArticleJournal of neurophysiology2015
Abnormal tuning of saccade-related cells in pontine reticular formation of strabismic monkeys.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Efficacy of binocular vision training and Fresnel press-on prism on children with esotropia and amblyopia.International ophthalmology · 2023Trial
- Saccade-Related Activity in Superior Colliculus Predicts Eye Choice for Goal-Directed Saccades in Monkeys With Strabismus.Investigative ophthalmology & visual science · 2025Article
- Disconjugacies of saccade duration and trajectories in strabismus.Strabismus · 2024Article
- Microstimulation of Interstitial Nucleus of Cajal Evokes Directionally Disconjugate Eye Movements in Monkeys With Pattern Strabismus.Investigative ophthalmology & visual science · 2022Article
- Efficient Use of Vestibular Testing.Otolaryngologic clinics of North America · 2021Review
- Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Abnormal Tuning in Nucleus Prepositus Hypoglossi of Monkeys With "A" Pattern Exotropia.Investigative ophthalmology & visual science · 2020Article
- Response Properties of Cells Within the Rostral Superior Colliculus of Strabismic Monkeys.Investigative ophthalmology & visual science · 2019Article
- Abnormal Eye Position Signals in Interstitial Nucleus of Cajal in Monkeys With "A" Pattern Strabismus.Investigative ophthalmology & visual science · 2019Article
- A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. I. Behavioral Comparisons to Vergence in a Normal Animal.Investigative ophthalmology & visual science · 2019Article
- A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. II. Abnormal Near Response Cell Activity in the Supraoculomotor Area.Investigative ophthalmology & visual science · 2019Article
- Horizontal Saccadic Velocity in Patients with Exotropia before and after Unilateral Resection and Recession Surgery.Journal of ophthalmology · 2019Article
- Activity of near-response cells during disconjugate saccades in strabismic monkeys.Journal of neurophysiology · 2018Article
- Visualizing Neuronal Adaptation Over Time After Treatment of Strabismus.Investigative ophthalmology & visual science · 2018Article
- Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness.ILAR journal · 2017Review
- Comparison of three models of saccade disconjugacy in strabismus.Journal of neurophysiology · 2017Article
- Neural mechanisms of oculomotor abnormalities in the infantile strabismus syndrome.Journal of neurophysiology · 2017Review
- Electrical stimulation of superior colliculus affects strabismus angle in monkey models for strabismus.Journal of neurophysiology · 2017Article
- Strabismus and the Oculomotor System: Insights from Macaque Models.Annual review of vision science · 2016Article
- Electrical Microstimulation of the Superior Colliculus in Strabismic Monkeys.Investigative ophthalmology & visual science · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Strabismus is a common disorder, characterized by a chronic misalignment of the eyes and numerous visual and oculomotor abnormalities. For example, saccades are often highly disconjugate. For humans with pattern strabismus, the horizontal and vertical disconjugacies vary with eye position. In monkeys, manipulations that disturb binocular vision during the first several weeks of life result in a chronic strabismus with characteristics that closely match those in human patients. Early onset strabismus is associated with altered binocular sensitivity of neurons in visual cortex. Here we test the hypothesis that brain stem circuits specific to saccadic eye movements are abnormal. We targeted the pontine paramedian reticular formation, a structure that directly projects to the ipsilateral abducens nucleus. In normal animals, neurons in this structure are characterized by a high-frequency burst of spikes associated with ipsiversive saccades. We recorded single-unit activity from 84 neurons from four monkeys (two normal, one exotrope, and one esotrope), while they made saccades to a visual target on a tangent screen. All 24 neurons recorded from the normal animals had preferred directions within 30° of pure horizontal. For the strabismic animals, the distribution of preferred directions was normal on one side of the brain, but highly variable on the other. In fact, 12/60 neurons recorded from the strabismic animals preferred vertical saccades. Many also had unusually weak or strong bursts. These data suggest that the loss of corresponding binocular vision during infancy impairs the development of normal tuning characteristics for saccade-related neurons in brain stem.
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