Evidence map›Paper›PMID 26063768›Full record

Observational studyClinical journal of the American Society of Nephrology : CJASN2015

The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation.

Ivar A Eide, Trond Jenssen, Anders Hartmann, Lien M Diep, Dag O Dahle, Anna V Reisæter, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, My Svensson

Open access · bronzeAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Fish oil for kidney transplant recipients.The Cochrane database of systematic reviews · 2016
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. The Effect of MarineNutrients · 2019
    Trial
  7. Effects of MarineNutrients · 2018
    Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Ivar A EideDepartment of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; ivaeid@ous-hf.no.
Trond JenssenDepartment of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; Metabolic and Renal Research Group, University of Tromsø The Arctic University of Norway, Tromsø, Norway;
Anders HartmannDepartment of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, The University of Oslo, Oslo, Norway;
Lien M DiepDepartment of Biostatistics, Epidemiology and Health Care Economics, Oslo University Hospital, Oslo, Norway;
Dag O DahleDepartment of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway;
Anna V ReisæterDepartment of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Oslo, Norway; The Norwegian Renal Registry, Oslo University Hospital, Rikshospitalet, Oslo, Norway;
Kristian S BjerveDepartment of Medical Biochemistry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; and.
Jeppe H ChristensenDepartments of Nephrology and.
Erik B SchmidtCardiology, Aalborg University Hospital, Aalborg, Denmark; and.
My SvenssonDepartment of Nephrology, Aarhus University Hospital, Aarhus, Denmark.
Oslo University Hospital · NOAalborg University Hospital · DKAarhus University Hospital · DKPediatric Nephrology of Alabama · USSt Olav's University Hospital · NOUiT The Arctic University of Norway · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSeveral studies have reported beneficial cardiovascular effects of marine n-3 polyunsaturated fatty acids. To date, no large studies have investigated the potential benefits of marine n-3 polyunsaturated fatty acids in recipients of renal transplants. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this observational cohort study of 1990 Norwegian recipients of renal transplants transplanted between 1999 and 2011, associations between marine n-3 polyunsaturated fatty acid levels and mortality were investigated by stratified analysis and multivariable Cox proportional hazard regression analysis adjusting for traditional and transplant-specific mortality risk factors. Marine n-3 polyunsaturated fatty acid levels in plasma phospholipids were measured by gas chromatography in a stable phase 10 weeks after transplantation.

resultsThere were 406 deaths (20.4%) during a median follow-up period of 6.8 years. Mortality rates were lower in patients with high marine n-3 polyunsaturated fatty acid levels (≥7.95 weight percentage) compared with low levels (<7.95 weight percentage) for all age categories (pooled mortality rate ratio estimate, 0.69; 95% confidence interval, 0.57 to 0.85). When divided into quartiles according to marine n-3 polyunsaturated fatty acid levels, patients in the upper quartile compared with the lower quartile had a 56% lower risk of death (adjusted hazard ratio, 0.44; 95% confidence interval, 0.26 to 0.75) using multivariable Cox proportional hazard regression analysis. There was a lower hazard ratio for death from cardiovascular disease with high levels of marine n-3 polyunsaturated fatty acid and a lower hazard ratio for death from infectious disease with high levels of the marine n-3 polyunsaturated fatty acid eicosapentaenoic acid, whereas there was no association between total or individual marine n-3 polyunsaturated fatty acid levels and cancer mortality.

conclusionsHigher plasma phospholipid marine n-3 polyunsaturated fatty acid levels were independently associated with better patient survival.

Indexed as

FishesKidney TransplantationSeafoodAdolescentAdultAgedAged, 80 and overAnimalsCause of DeathChromatography, GasCohort StudiesFatty Acids, Omega-3FemaleHumansKaplan-Meier EstimateLinear ModelsFatty Acids, Omega-3mortalitysurvivaltransplantationω3 fatty acids

Identifiers

PMID26063768
PMCPMC4491303
OpenAlexW2105325956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.