Evidence map›Paper›PMID 26063590›Full record

ArticleMolecular neurobiology2016

Plasma Homocysteine Levels Predict the Risk of Acute Cerebral Infarction in Patients with Carotid Artery Lesions.

Wei Wu, Yi Guan, Kan Xu, Xi-Jia Fu, Xiao-Feng Lei, Li-Jian Lei, Zhi-Qing Zhang, Yan Cheng, Yun-Qian Li

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

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  18. Serum cystatin C is associated with carotid atherosclerosis in patients with acute ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wei WuDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Yi GuanDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Kan XuDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Xi-Jia FuDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Xiao-Feng LeiDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Li-Jian LeiDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Zhi-Qing ZhangDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Yan ChengDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China.
Yun-Qian LiDepartment of Neurosurgery, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, People's Republic of China. liyunqian0512@163.com.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 umol/L). High-resolution B-mode ultrasounds were performed to assess intima media thickness (IMT), infarcts, plaques, and stenosis in the extracranial carotid artery of these patients. All patients underwent 3 T MR scanners to evaluate cerebral artery stenosis in the intracranial cerebral artery. The plasma Hcy levels did not show any statistically significant differences when comparisons were based on gender, age, blood pressure, diabetes, hyperlipidemia, and systolic and diastolic pressures. Importantly, the incidence of carotid plaque and severe stenosis of intracranial and extracranial artery were significantly higher in the high Hcy group compared to the low Hcy group. Pearson's test indicated that plasma Hcy levels positively correlated with IMT, total number of plaques and unstable plaques. Overall, the elevated plasma Hcy levels correlated with increased frequency of carotid plaque formation, extra- and intracranial arterial stenosis, and the degree of stenosis. In conclusion, we find a significant correlation between elevated plasma Hcy levels and the increased incidence of acute cerebral infarction in patients with carotid artery lesions.

Indexed as

AdultAgedAged, 80 and overArteriosclerosisCarotid ArteriesCarotid Intima-Media ThicknessCarotid StenosisCerebral InfarctionCohort StudiesFemaleHomocysteineHumansMaleMiddle AgedRisk FactorsHomocysteineAcute cerebral infarctionBlood pressureCarotid plaqueCarotid stenosisHomocysteineHyperlipidemia

Identifiers

PMID26063590
OpenAlexW659565176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.