ArticleGenes & development2015
Minishelterins separate telomere length regulation and end protection in fission yeast.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.bioRxiv : the preprint server for biology · 2025Article
- A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.microPublication biology · 2025Article
- Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.Nucleic acids research · 2024Article
- Rap1 prevents fusions between long telomeres in fission yeast.The EMBO journal · 2022Article
- Inhibition of MRN activity by a telomere protein motif.Nature communications · 2021Article
- Mechanism of MRX inhibition by Rif2 at telomeres.Nature communications · 2021Article
- Article
- Tpz1Communications biology · 2019Article
- Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.The EMBO journal · 2018Article
- Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.Nature communications · 2018Article
- Fission yeast Ccq1 is a modulator of telomerase activity.Nucleic acids research · 2018Article
- TRFH domain: at the root of telomere protein evolution?Cell research · 2018Article
- Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.Cell research · 2017Article
- Structural Basis for Shelterin Bridge Assembly.Molecular cell · 2017Article
- The proper connection between shelterin components is required for telomeric heterochromatin assembly.Genes & development · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The conserved shelterin complex is critical for chromosome capping and maintaining telomere length homeostasis. In fission yeast, shelterin is comprised of five proteins. Taz1, Rap1, and Poz1 function as negative regulators of telomere elongation, whereas Pot1 and Tpz1 are critical for end capping and telomerase recruitment. How the five proteins work together to safeguard chromosome ends and promote telomere length homeostasis is a matter of great interest. Using a combination of deletions, fusions, and tethers, we define key elements of shelterin important for telomere length regulation. Surprisingly, deletion of the entire Rap1 and Poz1 proteins does not impair telomere length regulation as long as a static bridge is provided between Taz1 and Tpz1. Cells harboring minishelterin display wild-type telomere length and intact subtelomeric silencing. However, protection against end fusions in G1 is compromised in the absence of Rap1. Our data reveal a remarkable plasticity in shelterin architecture and separate functions in length regulation and end protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.