ArticleBMJ open2015
Developments in the invasive diagnostic-therapeutic cascade of women and men with acute coronary syndromes from 2005 to 2011: a nationwide cohort study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- The Effect of 3-Month Growth Hormone Administration and 12-Month Follow-Up Duration among Heart Failure Patients Four Weeks after Myocardial Infarction: A Randomized Double-Blinded Clinical Trial.Cardiovascular therapeutics · 2021Trial
- Gender related outcome differences in off-pump coronary artery bypass grafting.Frontiers in cardiovascular medicine · 2025Article
- Sex differences in coronary artery bypass graft surgery outcomes: a narrative review.Journal of thoracic disease · 2023Review
- Review
- Sex-Related Outcomes of Medical, Percutaneous, and Surgical Interventions for Coronary Artery Disease: JACC Focus Seminar 3/7.Journal of the American College of Cardiology · 2022Review
- Sex differences in treatment and outcomes of patients with in-hospital ST-elevation myocardial infarction.Clinical cardiology · 2022Article
- Health-related quality of life in men and women who experienced cardiovascular diseases: Tehran Lipid and Glucose Study.Health and quality of life outcomes · 2021Article
- Are there sex differences in the effect of type 2 diabetes in the incidence and outcomes of myocardial infarction? A matched-pair analysis using hospital discharge data.Cardiovascular diabetology · 2021Observational
- Gender Equity in Access to Reperfusion in Acute Myocardial Infarction: Still A Long Way to Go.Arquivos brasileiros de cardiologia · 2021Article
- Sex Differences Persist in Time to Presentation, Revascularization, and Mortality in Myocardial Infarction Treated With Percutaneous Coronary Intervention.Journal of the American Heart Association · 2019Observational
- Use of diagnostic coronary angiography in women and men presenting with acute myocardial infarction: a matched cohort study.BMC cardiovascular disorders · 2016Observational
- Characteristics of and outcomes for elderly patients with acute myocardial infarction: differences between females and males.Clinical interventions in aging · 2016Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate for trends in sex-related differences in the invasive diagnostic-therapeutic cascade in a population of patients with acute coronary syndromes (ACS).
designA nationwide cohort study.
settingAdministrative and clinical registries covering all hospitalisations, invasive cardiac procedures and deaths in the Danish population of 5.6 million inhabitants.
participantsWe included 52,565 patients aged 30-90 years who were hospitalised with a first ACS from January 2005 to November 2011. Follow-up was 60 days from the day of index admission.
main outcome measuresDiagnostic coronary angiography, percutaneous coronary intervention or coronary artery bypass within 60 days of index admission.
resultsWomen constituted 36%, were older, had more comorbidity and were less likely to be admitted to a hospital with cardiac catheterisation facilities than men. Mortality rates were similar for both sexes. Diagnostic coronary angiography was performed less frequently on women compared with men, both within 1 day (31% vs 42%; p<0.001) and within 60 days (67% vs 80%; p<0.001), yielding adjusted female-male HRs of 0.83 (0.79-0.87) and 0.86 (0.84-0.89), respectively.Among the 39,677 patients undergoing coronary angiography, non-obstructive coronary artery disease was more frequent among women than men (22% vs 9%; p<0.001). Women were less likely to undergo percutaneous coronary intervention (58% vs 72%; p<0.001) and coronary artery bypass (6% vs 11%, p<0.001) within 60 days than men, yielding adjusted HRs of 0.96 (0.92-0.99) and 0.81 (0.74-0.89), respectively. The sex-related differences were not attenuated over time for any of the invasive cardiac procedures (p values for trend >0.05).
conclusionsIn this nationwide study, men were more likely to undergo an invasive approach than women when hospitalised with a first ACS--a difference persisting from 2005 to 2011. Future studies should focus on the potential mechanisms behind this differential treatment.
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