Evidence map›Paper›PMID 26063567›Full record

ArticleBMJ open2015

Magnetoencephalography to investigate central perception of exercise-induced breathlessness in people with chronic lung disease: a feasibility pilot.

Miriam J Johnson, Michael Ig Simpson, David C Currow, Rebecca E Millman, Simon P Hart, Gary Green

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

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  4. Application of Fan Therapy in Alleviating Dyspnea.Journal of multidisciplinary healthcare · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Miriam J JohnsonHull York Medical School, University of Hull, Hull, UK.
Michael Ig SimpsonYork Neuroimaging Centre, University of York, York, UK.
David C CurrowDiscipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia.
Rebecca E MillmanYork Neuroimaging Centre, University of York, York, UK.
Simon P HartHull York Medical School, University of Hull, Hull, UK.
Gary GreenHull York Medical School, University of Hull, Hull, UK York Neuroimaging Centre, University of York, York, UK Department of Psychology, University of York, York, UK.
University of York · GBFlinders University · AUHull York Medical School · GBUniversity of Hull · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNeuroimaging in chronic breathlessness is challenging. The study objective was to test the feasibility of magnetoencephalography (MEG) for functional neuroimaging of people with chronic breathlessness.

designFeasibility pilot study.

settingRespiratory clinic out-patients.

participants8 patients (mean age=62; (range 47-83); 4 men) with chronic non-malignant lung disease; modified MRC breathlessness score ≥ (median mMRC=4), intensity of exercise-induced breathlessness >3/10; no contraindication to MRI scanning. METHODS AND MEASURES: 4 MEG scans were conducted for each participant: (1) at rest (5 mins), (2) postseated leg exercise-induced breathlessness during recovery (10 mins). Recovery scans (2) were conducted with/without facial airflow in random order; both scans were repeated 1 h later. Participants rated breathlessness intensity (0-10 Numerical Rating Scale (NRS)) at baseline, maximal exertion and every minute during recovery, and rated acceptability of study procedures at the end of the study (0-10 NRS). A structural MRI scan was conducted for MEG coregistration and source-space analyses. Rest data were compared with data from healthy volunteers (N=6; 5 men; mean age=30.7 years ± 3.9 years).

resultsExercises and MEG scanning were acceptable to all participants; 7/8 completed the MRI scans. Maximum breathlessness intensity was induced by 5 min' exercise. The same level was induced for repeat scans (median=8; IQR=7-8). All recovered to baseline by 10 min. Time-frequency profiles of data from the first and last 3 min were analysed in MEG source space based on breathlessness location estimates. Source localisation was performed, but anatomical source inference was limited to the level of the lobe. Differences in areas of activity were seen: during recovery scans; with and without airflow; and between participants/normal volunteers at rest.

conclusionsMEG is a feasible method to investigate exercise-induced breathlessness in people breathless with chronic lung disease, and able to identify neural activity related to changes in breathlessness.

Indexed as

DyspneaMagnetoencephalographyAgedAged, 80 and overBrainChronic DiseaseExerciseFeasibility StudiesFemaleHumansLung DiseasesMagnetic Resonance ImagingMaleMiddle AgedPilot ProjectsPulmonary Ventilation

Identifiers

PMID26063567
PMCPMC4574009
OpenAlexW2229900744

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.