Evidence map›Paper›PMID 26063561›Full record

ArticleJournal of human hypertension2016

Hypertension and mortality in the Golestan Cohort Study: A prospective study of 50 000 adults in Iran.

S G Sepanlou, M Sharafkhah, H Poustchi, M M Malekzadeh, A Etemadi, H Khademi, F Islami, A Pourshams, P D Pharoah, C C Abnet and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Burden of hypertension-related diseases in Eastern Mediterranean region.Journal of Taibah University Medical Sciences · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

S G SepanlouDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
M SharafkhahDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
H PoustchiDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
M M MalekzadehDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
A EtemadiDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
H KhademiDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0001-8145-1724
F IslamiDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
A PourshamsDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
P D PharoahDepartments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, UK.
C C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
P BrennanInternational Agency for Research on Cancer, Lyon, France.
P BoffettaThe Tisch Cancer Institute, and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S M DawseyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
A EsteghamatiEndocrinology and Metabolism Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
F KamangarDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
R MalekzadehDigestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shariati Hospital · IRNational Cancer Institute · USAmerican Cancer Society · USCentre international de recherche sur le cancer · FRTehran University of Medical Sciences · IRTisch Hospital · USUniversity of Cambridge · GB

Funding

Cancer Research UK 10119Cancer Research UK 10124Intramural NIH HHSWorld Health Organization 001
6 · The paper itself

Abstract

High blood pressure has been the second most important determinant of disease burden in Iran since the 1990s. Despite well-recognized evidence on the association of high blood pressure and mortality in other countries, this relationship has not been fully investigated in the demographic setting of Iran. The current study is the first large-scale longitudinal study of this association in Iran. Briefly, 50 045 subjects between 40 and 75 years of age have been recruited and followed. Blood pressure measurements were carried out at baseline. Causes of death were reported and verified by verbal autopsy throughout the follow-up period. The outcomes of interest were all-cause deaths and deaths due to ischemic heart disease (IHD) or stroke. Cox proportional hazards regression models were used to estimate hazard ratios (HRs). A total of 46 674 subjects free from cardiovascular disease at baseline were analyzed. Absolute mortality rates increased along with increasing systolic or diastolic blood pressure above 120 and 80 mm Hg, respectively. Adjusted HRs (95% confidence intervals) for each 20 mm Hg increase in systolic blood pressure in all age groups were 1.18 (1.13-1.23) for all-cause mortality, 1.21 (1.13-1.31) for deaths due to IHD and 1.50 (1.39-1.63) for deaths due to stroke. Unadjusted and adjusted HRs were higher in younger subjects and decreased with increasing age of the participants. High blood pressure is a serious threat to the health of Iranians. The entire health-care system of Iran should be involved in a comprehensive action plan for controlling blood pressure.

Indexed as

Blood PressureAdultAgedAge FactorsCause of DeathFemaleHealth StatusHumansHypertensionIranLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk Factors

Identifiers

PMID26063561
OpenAlexW569624884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.