SynthesisPediatric dentistry
Effect of Antimicrobial Interventions on the Oral Microbiota Associated with Early Childhood Caries.
Synthesis in Pediatric dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07741409 (Povidone Iodine to Prevent Early Childhood Caries), which is not on this map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Povidone Iodine to Prevent Early Childhood Caries
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-research.Current pediatric reviews · 2026Pooled it
- Specific effects of xylitol chewing gum on mutans streptococci levels, plaque accumulation and caries occurrence: a systematic review.BMC oral health · 2025Pooled it
- The effect of xylitol chewing gums and candies on caries occurrence in children: a systematic review with special reference to caries level at study baseline.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Pooled it
- Prenatal Oral Health Care and Early Childhood Caries Prevention: A Systematic Review and Meta-Analysis.Caries research · 2019Pooled it
- Longitudinal Association Between Severe Early Childhood Caries and Mandibular Condylar Trabecular Organization: A 3-Year Retrospective Controlled Study.Journal of clinical medicine · 2026Article
- Green synthesis of silver-coated zinc oxide nanocomposite using the walnut green husk extract and assessment of its cytotoxicity and antimicrobial activity againstAvicenna journal of phytomedicine · 2026Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance.The Japanese dental science review · 2023Review
- Assessment of SARS-CoV-2 (COVID-19) Clinical Mouthwash Protocol and Prevalence of the Oral PathogenMethods and protocols · 2023Article
- Association between Bifidobacterium and Scardovia Wiggsiae and caries-related factors in severe early childhood caries and caries-free Thai children: a quantitative real-time PCR analysis and a questionnaire cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Article
- Streptococcus Mutans Infections in Infants and Related Maternal/Child Factors.Acta stomatologica Croatica · 2021Article
- Analysis of lymphocyte T(CD4Infectious disease reports · 2020Article
- Characterization ofMicroorganisms · 2020Article
- In vitro evaluation of the cariogenic potential of rebaudioside A compared to sucrose and xylitol.Clinical oral investigations · 2020Article
- A community-based pragmatic, controlled trial for preventing and reducing oral diseases among 1-6-year-old children visiting Anganwadi centers, under the Integrated Child Development Scheme, India.BMC public health · 2019Article
- Quality of abstract of systematic reviews and meta-analyses in paediatric dentistry journals.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2019Article
- Follow-up of an Intervention to Reduce Dental Caries in Indigenous Australian Children: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2019Article
- Xylitol and sorbitol effects on the microbiome of saliva and plaque.Journal of oral microbiology · 2019Article
- Inhibitory effect of reduced graphene oxide-silver nanocomposite on progression of artificial enamel caries.Journal of applied oral science : revista FOB · 2018Article
- Association between Oral Candida and Bacteriome in Children with Severe ECC.Journal of dental research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purposes of this systematic literature review were to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes; and to review methods used to perform microbial assessments in clinical studies of ECC.
methodsMultiple databases were searched; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, from which 41 studies were included in the meta-analyses.
resultsIn most of the reviewed studies, moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents, but bacterial regrowth occurred and new carious lesions developed once the treatment had ceased, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the long-term benefits of ECC prevention are lacking.
conclusionBased on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, there is insufficient evidence to indicate that the approaches used produced sustainable effects on cariogenic microbial colonization or ECC reduction and prevention.
Indexed as
Identifiers
26063552PMC4485441W610343353What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.