ArticleJournal of human genetics2015
Genetic analysis of common variants in the HDAC2 gene with schizophrenia susceptibility in Han Chinese.
Article in Journal of human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Association of common variants in H2AFZ gene with schizophrenia and cognitive function in patients with schizophrenia.Journal of human genetics · 2015Trial
- Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy.Scientific reports · 2019Article
- Evaluation of genetic susceptibility between systemic lupus erythematosus and GRB2 gene.Scientific reports · 2019Article
- IRAK2 and TLR10 confer risk of Hashimoto's disease: a genetic association study based on the Han Chinese population.Journal of human genetics · 2019Article
- Relationship of common variants in Interleukin 33 gene with susceptibility and prognosis of osteosarcoma in Han Chinese population.Journal of Cancer · 2019Article
- Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.Scientific reports · 2018Article
- Relationship of common variants in VEGFA gene with osteonecrosis of the femoral head: A Han Chinese population based association study.Scientific reports · 2018Article
- Genetic susceptibility of postmenopausal osteoporosis on sulfide quinone reductase-like gene.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- A common polymorphism of COMT was associated with symptomatic lumbar disc herniation based on a large sample with Chinese Han ancestry.Scientific reports · 2018Article
- Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population.Scientific reports · 2018Article
- MDM4 contributes to the increased risk of glioma susceptibility in Han Chinese population.Scientific reports · 2018Article
- Common variants in the GNL3 contribute to the increasing risk of knee osteoarthritis in Han Chinese population.Scientific reports · 2018Article
- Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population.Scientific reports · 2018Article
- Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population.PloS one · 2018Article
- Evaluation of the association ofOncotarget · 2017Article
- Epigenetic Regulation of Memory-Therapeutic Potential for Disorders.Current neuropharmacology · 2017Review
- Genetic association study identified a 20 kb regulatory element in WLS associated with osteoporosis and bone mineral density in Han Chinese.Scientific reports · 2017Article
- Genetic association study of common variants in TGFB1 and IL-6 with developmental dysplasia of the hip in Han Chinese population.Scientific reports · 2017Article
- Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients.Scientific reports · 2017Article
- Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SCZ) is a complex psychiatric disorder that is strongly influenced by a genetic component. Recent studies suggested that histone deacetylases (HDACs) might increase the expression of several key genes in the brain and may also be associated with susceptibility to SCZ. Among human HDACs, HDAC2 is a critical modulator of gene regulation. Here, we designed a two-stage case-control study to thoroughly examine the association between the HDAC2 gene and SCZ. A total of 19 common single-nucleotide polymorphisms (SNPs) in the region of the HDAC2 gene were analyzed in the test group of 1430 patients and 2862 matched healthy controls. A comparison of the genotype and allele frequencies of the SNPs between cases and controls revealed that three SNPs, rs13212283, rs6568819 and rs9488289, were nominally associated with SCZ. However, we failed to observe any association between these SNPs and SCZ in the validation group consisting of 896 cases and 1815 matched healthy controls. Furthermore, haplotypic analysis also confirmed the negative results. Our results provide preliminary evidence that HDAC2 may not confer susceptibility to SCZ in Han Chinese. Additional genetic studies from a large population are required to obtain more conclusive results.
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