Evidence map›Paper›PMID 26063439›Full record

ArticlePsychological science2015

Prenatal Programming of Postnatal Susceptibility to Memory Impairments: A Developmental Double Jeopardy.

Kerry-Ann Grant, Curt A Sandman, Deborah A Wing, Julia Dmitrieva, Elysia Poggi Davis

Abstract read
In one paragraph

Article in Psychological science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Stress and the HPA Axis: Balancing Homeostasis and Fertility.International journal of molecular sciences · 2017
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kerry-Ann GrantWomen and Children's Health and Well-Being Project, Department of Psychiatry and Human Behavior, University of California, Irvine.
Curt A SandmanWomen and Children's Health and Well-Being Project, Department of Psychiatry and Human Behavior, University of California, Irvine.
Deborah A WingDepartment of Obstetrics and Gynecology, University of California, Irvine.
Julia DmitrievaDepartment of Psychology, University of Denver.
Elysia Poggi DavisWomen and Children's Health and Well-Being Project, Department of Psychiatry and Human Behavior, University of California, Irvine Department of Psychology, University of Denver elysia.davis@du.edu.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
Vulnerability to Prenatal Glucocorticoids Programs Infant DevelopmentR01HD065823 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIS, ELYSIA POGGI · 2010 to 2014
$2.4M
Prenatal Glucocorticoids Influence Brain and BehaviorR01HD050662 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAVIS, ELYSIA POGGI · 2006 to 2010
$2.0M
NICHD NIH HHS HD-50662NICHD NIH HHS HD-6582NICHD NIH HHS R01 HD050662NICHD NIH HHS R01 HD065823NIMH NIH HHS MH-96889NIMH NIH HHS P50 MH096889
6 · The paper itself

Abstract

In the study reported here, we examined the effects of fetal exposure to a synthetic stress hormone (synthetic glucocorticoids) on children's susceptibility to postnatal sociodemographic adversity. We recruited children who were born healthy and at term. Twenty-six had been treated with steroid hormones (glucocorticoids) during the prenatal period, and 85 had not. Only children exposed to both prenatal stress hormones and postnatal sociodemographic adversity showed impaired performance on standardized tests of memory function. The association was specific to long-term memory. General intellectual functioning and expressive language were not affected by fetal glucocorticoid exposure. Results were independent of maternal intelligence and maternal depression at the time of the study. These findings are consistent with a vulnerability-stress model: Prenatal exposure to synthetic stress hormones is associated with increased susceptibility to subsequent adversity, with consequences for cognitive functioning that persist 6 to 10 years after birth.

Indexed as

ChildCognitionDisease SusceptibilityFemaleGlucocorticoidsHumansMaleMemory DisordersMemory, Long-TermPregnancyPrenatal Exposure Delayed EffectsRegression AnalysisGlucocorticoidsbetamethasonecognitioncortisolglucocorticoidsmemoryprenatalstress

Identifiers

PMID26063439
PMCPMC4504787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.