ArticleJournal of virology2015
Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Major bat-borne zoonotic viral epidemics in Asia and Africa: A systematic review and meta-analysis.Veterinary medicine and science · 2022Pooled it
- Exploring coronavirus cell entry with functional viromics.Journal of virology · 2026Review
- The crucial but insufficient role of E2s domain's residues 490 and 492 in determining the host tropism of hepatitis E virus.Nature communications · 2026Article
- MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors.Cell reports. Medicine · 2025Article
- Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2.Scientific reports · 2025Article
- Structures and receptor binding activities of merbecovirus spike proteins reveal key signatures for human DPP4 adaptation.Science advances · 2025Article
- Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and Their Housemates.Viruses · 2025Article
- Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses.Cell · 2025Article
- The Batalogue: an overview of betacoronaviruses with future pandemic potential.FEMS microbiology reviews · 2025Review
- Acquisition of a multibasic cleavage site does not increase MERS-CoV entry into Calu-3 human lung cells.Journal of virology · 2024Article
- Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses.bioRxiv : the preprint server for biology · 2024Article
- Investigation of the effects ofComputational & theoretical chemistry · 2023Article
- Identification and Genetic Characterization of MERS-Related Coronavirus Isolated from Nathusius' Pipistrelle (International journal of environmental research and public health · 2023Article
- Article
- Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 Variants.The protein journal · 2022Article
- Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from China.International journal of molecular sciences · 2022Article
- The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2.Molecular biology and evolution · 2022Review
- Hotspots for mutations in the SARS-CoV-2 spike glycoprotein: a correspondence analysis.Scientific reports · 2021Article
- Glycosylation of SARS-CoV-2: structural and functional insights.Analytical and bioanalytical chemistry · 2021Review
- The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.PLoS pathogens · 2021Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explaining why MERS-CoV infects human cells. These mutations therefore played critical roles in the bat-to-human transmission of MERS-CoV, either directly or through intermediate hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.