ArticleChinese medical journal2015
Comparison of Cerebral Metabolism between Pig Ventricular Fibrillation and Asphyxial Cardiac Arrest Models.
Article in Chinese medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Cerebral Oxygen Saturation Responsiveness During Cardiopulmonary Resuscitation After Prolonged Ventricular Fibrillation: A Porcine Study.Journal of clinical medicine · 2026Article
- 18F-FDG PET/CT for post-cardiac-arrest brain injury: current evidence and future directions.Frontiers in neurology · 2026Review
- A modified rat model of 8 minutes asphyxial cardiac arrest and cardiopulmonary resuscitation.PloS one · 2025Article
- Differences in Cerebral Oxygenation in Cardiogenic and Respiratory Cardiac Arrest Before, During, and After Cardiopulmonary Resuscitation.Journal of clinical medicine · 2023Article
- Extracorporeal Cardiopulmonary Resuscitation Guided by End-Tidal Carbon Dioxide-a Porcine Model.Journal of cardiovascular translational research · 2022Article
- Brain Activity after Intermittent Hypoxic Brain Condition in Rats.Brain sciences · 2021Article
- Cardiac Arrest Induced by Asphyxia Versus Ventricular Fibrillation Elicits Comparable Early Changes in Cytokine Levels in the Rat Brain, Heart, and Serum.Journal of the American Heart Association · 2021Article
- Mild hypercapnia improves brain tissue oxygen tension but not diffusion limitation in asphyxial cardiac arrest: an experimental study in pigs.BMC anesthesiology · 2020Article
- Positron Emission Tomography After Ischemic Brain Injury: Current Challenges and Future Developments.Translational stroke research · 2020Review
- Type 2 diabetes mellitus worsens neurological injury following cardiac arrest: an animal experimental study.Intensive care medicine experimental · 2018Article
- Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology.Critical care medicine · 2018Observational
- Comparison of Quantitative Characteristics of Early Post-resuscitation EEG Between Asphyxial and Ventricular Fibrillation Cardiac Arrest in Rats.Neurocritical care · 2018Article
- Metabolomics profiling reveals different patterns in an animal model of asphyxial and dysrhythmic cardiac arrest.Scientific reports · 2017Article
- Pathophysiology and the Monitoring Methods for Cardiac Arrest Associated Brain Injury.International journal of molecular sciences · 2017Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMorbidity and mortality after resuscitation largely depend on the recovery of brain function. Ventricular fibrillation cardiac arrest (VFCA) and asphyxial cardiac arrest (ACA) are the two most prevalent causes of sudden cardiac death. Up to now, most studies have focused on VFCA. However, results from the two models have been largely variable. So, it is necessary to characterize the features of postresuscitation cerebral metabolism of both models.
methodsForty-four Wuzhishan miniature inbred pigs were randomly divided into three groups: 18 for VFCA group, ACA group, respectively, and other 8 for sham-operated group (SHAM). VFCA was induced by programmed electric stimulation, and ACA was induced by endotracheal tube clamping. After 8 min without treatment, standard cardiopulmonary resuscitation (CPR) was initiated. Following neurological deficit scores (NDS) were evaluated at 24 h after achievement of spontaneous circulation, cerebral metabolism showed as the maximum standardized uptake value (SUVmax) was measured by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography. Levels of serum markers of brain injury, neuron specific enolase (NSE), and S100β were quantified with an enzyme-linked immunosorbent assay.
resultsCompared with VFCA group, fewer ACA animals achieved restoration of spontaneous circulation (61.1% vs. 94.4%, P < 0.01) and survived 24-h after resuscitation (38.9% vs. 77.8%, P < 0.01) with worse neurological outcome (NDS: 244.3 ± 15.3 vs. 168.8 ± 9.71, P < 0.01). The CPR duration of ACA group was longer than that of VFCA group (8.1 ± 1.2 min vs. 4.5 ± 1.1 min, P < 0.01). Cerebral energy metabolism showed as SUVmax in ACA was lower than in VFCA (P < 0.05 or P < 0.01). Higher serum biomarkers of brain damage (NSE, S100β) were found in ACA than VFCA after resuscitation (P < 0.01).
conclusionsCompared with VFCA, ACA causes more severe cerebral metabolism injuries with less successful resuscitation and worse neurological outcome.
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