Evidence map›Paper›PMID 26063350›Full record

Observational studyReproductive health2015

Adverse maternal and perinatal outcomes in adolescent pregnancies: The Global Network's Maternal Newborn Health Registry study.

Fernando Althabe, Janet L Moore, Luz Gibbons, Mabel Berrueta, Shivaprasad S Goudar, Elwyn Chomba, Richard J Derman, Archana Patel, Sarah Saleem, Omrana Pasha and 12 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Reproductive health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01073475 (Global Network for Women's and Children's Health Research Maternal Newborn Health Registry), which is not on this map. Cited by 114 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 4 pooled it
35.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01073475 recruitingnot on this map

Global Network for Women's and Children's Health Research Maternal Newborn Health Registry

TypeobservationalSponsorNICHD Global Network for Women's and Children's HealthRan2008 to 2030Enrolled950,000ConditionsPregnancy Outcome Trends in Low-resource Geographic AreasArmsThere is no intervention associated with the parent MNHR study. For the MNHR COVID sub-study, participants will be asked to provide a blood specimen at or near delivery.
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 4 syntheses or guidelines pooled it, 272 citations in OpenAlex.

  1. Intimate partner violence during pregnancy against adolescents in sub-Saharan Africa: a systematic review.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2024
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 17 institutions in 7 countries.

Fernando Althabe
Janet L Moore
Luz Gibbons
Mabel Berrueta
Shivaprasad S Goudar
Elwyn Chomba
Richard J Derman
Archana Patel
Sarah Saleem
Omrana Pasha
Fabian Esamai
Ana Garces
Edward A Liechty
K Hambidge
Nancy F Krebs
Patricia L Hibberd
Robert L Goldenberg
Marion Koso-Thomas
Waldemar A Carlo
Maria L Cafferata
Pierre Buekens
Elizabeth M McClure
Instituto de Efectividad Clínica y Sanitaria · ARAga Khan University · PKRTI International · USBoston Children's Hospital · USChristiana Care Health System · USColumbia University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USIndiana University – Purdue University Indianapolis · USInstitute of Nutrition of Central America and Panama · GTJawaharlal Nehru Medical College · INLata Medical Research Foundation · INMassachusetts General Hospital · USMoi University · KETulane University · USUniversity of Alabama at Birmingham · USUniversity of Colorado Denver · USUniversity of Zambia · ZM

Funding

UAB/AKU Global Network Research UnitU01HD040607 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOLDENBERG, ROBERT L · 2001 to 2012
$8.5M
Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research UnitUG1HD078439 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Patricia L Hibberd · 2018 to 2026
$5.5M
Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
The Global Network and Preconception Maternal NutritionU10HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KREBS, NANCY F · 2013 to 2017
$5.1M
Global Network for Women's and Children's Health ResearchU10HD076461 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI LIECHTY, EDWARD A. · 2013 to 2017
$4.1M
CCHS-JNMC Global Network for Women's & Children's Health Research UnitU10HD076457 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI DERMAN, RICHARD J · 2013 to 2017
$3.7M
Heart Rate Detection during Resuucitation to Reduce Early Neonatal MortalityU10HD078437 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 2013 to 2017
$3.3M
Global Network for Women's and Children's Health ResearchUG1HD076461 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI BUCHER, SHERRI LYNN, SZYLD, EDGARDO GABRIEL · 2018 to 2023
$3.2M
Columbia University/Aga Khan University Global Network Research UnitU10HD078438 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOLDENBERG, ROBERT L · 2013 to 2017
$3.2M
Maternal and Child Health Benefits from Reducing Household Air PollutionU10HD078439 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HIBBERD, PATRICIA L · 2013 to 2017
$3.1M
NICHD NIH HHS U01 HD040607NICHD NIH HHS U10 HD076457NICHD NIH HHS U10 HD076461NICHD NIH HHS U10 HD076474NICHD NIH HHS U10 HD078437NICHD NIH HHS U10 HD078438NICHD NIH HHS U10 HD078439NICHD NIH HHS UG1 HD076461NICHD NIH HHS UG1 HD076474NICHD NIH HHS UG1 HD078439
6 · The paper itself

Abstract

backgroundAdolescent girls between 15 and 19 years give birth to around 16 million babies each year, around 11% of births worldwide. We sought to determine whether adolescent mothers are at higher risk of maternal and perinatal adverse outcomes compared with mothers aged 20-24 years in a prospective, population-based observational study of newborn outcomes in low resource settings.

methodsWe undertook a prospective, population-based multi-country research study of all pregnant women in defined geographic areas across 7 sites in six low-middle income countries (Kenya, Zambia, India, Pakistan, Guatemala and Argentina). The study population for this analysis was restricted to women aged 24 years or less, who gave birth to infants of at least 20 weeks' gestation and 500g or more. We compared adverse pregnancy maternal and perinatal outcomes among pregnant adolescents 15-19 years, <15 years, and adults 20-24 years.

resultsA total of 269,273 women were enrolled from January 2010 to December 2013. Of all pregnancies 11.9% (32,097/269,273) were in adolescents 15-19 years, while 0.14% (370/269,273) occurred among girls <15 years. Pregnancy among adolescents 15-19 years ranged from 2% in Pakistan to 26% in Argentina, and adolescent pregnancies <15 year were only observed in sub-Saharan Africa and Latin America. Compared to adults, adolescents did not show increased risk of maternal adverse outcomes. Risks of preterm birth and LBW were significantly higher among both early and older adolescents, with the highest risks observed in the <15 years group. Neonatal and perinatal mortality followed a similar trend in sub-Saharan Africa and Latin America, with the highest risk in early adolescents, although the differences in this age group were not significant. However, in South Asia the risks of neonatal and perinatal death were not different among adolescents 15-19 years compared to adults.

conclusionsThis study suggests that pregnancy among adolescents is not associated with worse maternal outcomes, but is associated with worse perinatal outcomes, particularly in younger adolescents. However, this may not be the case in regions like South Asia where there are decreasing rates of adolescent pregnancies, concentrated among older adolescents. The increased risks observed among adolescents seems more likely to be associated with biological immaturity, than with socio-economic factors, inadequate antenatal or delivery care. TRIAL REGISTRATION NUMBER: NCT01073475.

Indexed as

Pregnancy in AdolescenceAdolescentAge FactorsDelivery, ObstetricDeveloping CountriesEducational StatusFemaleHumansInfantInfant MortalityInfant, NewbornMaternal AgePregnancyPregnancy OutcomePremature BirthPrenatal Care

Identifiers

PMID26063350
PMCPMC4464033
OpenAlexW1500757970

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.