Evidence map›Paper›PMID 26063080›Full record

ReviewJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2015

Defining Post Hepatectomy Liver Insufficiency: Where do We stand?

Kelly Lafaro, Stefan Buettner, Hadia Maqsood, Doris Wagner, Fabio Bagante, Gaya Spolverato, Li Xu, Ihab Kamel, Timothy M Pawlik

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Updates and Critical Insights on Glissonian Approach in Liver Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelly LafaroDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stefan BuettnerDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hadia MaqsoodDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Doris WagnerDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fabio BaganteDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gaya SpolveratoDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Li XuDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ihab KamelDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timothy M PawlikDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. tpawlik1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-hepatectomy liver failure (PHLF) is a major source of morbidity and mortality in patients undergoing liver resection. The aim of this review is to summarize the recent literature available on PHLF including its definition, predictive factors, preoperative risk assessment, severity grading, preventative measures, and management strategies.

methodsA systematic literature search was carried out with the search engines PubMed, Medline, and Cochrane Database using the keywords related to "liver failure", "posthepatectomy", and "hepatic resection".

resultsLiver resection is a curative treatment of liver tumors. However, it leads to concurrent death and regeneration of the remaining hepatocytes. Factors related to the patient, liver parenchyma and the extent of surgery can inhibit regeneration leading to PHLF.

conclusionGiven its resistance to treatment and the high postoperative mortality associated with PHLF, great effort has been put in to both accurately identify patients at high risk and to develop strategies that can help prevent its occurrence.

Indexed as

HepatectomyHumansLiver FailureLiver NeoplasmsRisk AssessmentComplicationsHepatectomyLiver failureRisk modelsSurgery/mortality

Identifiers

PMID26063080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.