Evidence map›Paper›PMID 26063068›Full record

Trial reportThe Journal of nutrition2015

Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates.

Gengli Zhao, Guobin Xu, Min Zhou, Yaping Jiang, Blair Richards, Katy M Clark, Niko Kaciroti, Michael K Georgieff, Zhixiang Zhang, Twila Tardif and 2 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02221752 (Impact of Iron/Folic Acid Versus Folic Acid Supplements During Pregnancy on Maternal and Children's Health), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02221752 nacompletednot on this map

Impact of Iron/Folic Acid Versus Folic Acid Supplements During Pregnancy on Maternal and Children's Health: A Randomized Controlled Trial in China

TypeinterventionalSponsorZhao gengliRan2009 to 2011Enrolled2,367ConditionsIron Deficiency, Iron Deficiency AnemiaArmsFerrous Sulfate + folic acid, Folic acid
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024
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  14. Inadequate iron stores in early term neonates.Journal of perinatology : official journal of the California Perinatal Association · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Gengli ZhaoPeking University First Hospital, Beijing, China;
Guobin XuPeking University First Hospital, Beijing, China;
Min ZhouPeking University First Hospital, Beijing, China;
Yaping JiangPeking University First Hospital, Beijing, China;
Blair RichardsCenter for Human Growth and Development and.
Katy M ClarkCenter for Human Growth and Development and.
Niko KacirotiCenter for Human Growth and Development and.
Michael K GeorgieffDepartment of Pediatrics, University of Minnesota, Minneapolis, MN.
Zhixiang ZhangPeking University First Hospital, Beijing, China;
Twila TardifCenter for Human Growth and Development and.
Ming LiPeking University First Hospital, Beijing, China;
Betsy LozoffCenter for Human Growth and Development and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI; and blozoff@umich.edu.
Peking University · CNUniversity of Michigan · USUniversity of Minnesota · US

Funding

Timing, Duration and Severity of Infant Iron Deficiency: Developmental ImpactsR01HD052069 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOZOFF, BETSY · 2007 to 2011
$3.9M
NICHD NIH HHS R01 HD052069
6 · The paper itself

Abstract

backgroundPrevious trials of prenatal iron supplementation had limited measures of maternal or neonatal iron status.

objectiveThe purpose was to assess effects of prenatal iron-folate supplementation on maternal and neonatal iron status.

methodsEnrollment occurred June 2009 through December 2011 in Hebei, China. Women with uncomplicated singleton pregnancies at ≤20 wk gestation, aged ≥18 y, and with hemoglobin ≥100 g/L were randomly assigned 1:1 to receive daily iron (300 mg ferrous sulfate) or placebo + 0.40 mg folate from enrollment to birth. Iron status was assessed in maternal venous blood (at enrollment and at or near term) and cord blood. Primary outcomes were as follows: 1) maternal iron deficiency (ID) defined in 2 ways as serum ferritin (SF) <15 μg/L and body iron (BI) <0 mg/kg; 2) maternal ID anemia [ID + anemia (IDA); hemoglobin <110 g/L]; and 3) neonatal ID (cord blood ferritin <75 μg/L or zinc protoporphyrin/heme >118 μmol/mol).

resultsA total of 2371 women were randomly assigned, with outcomes for 1632 women or neonates (809 placebo/folate, 823 iron/folate; 1579 mother-newborn pairs, 37 mothers, 16 neonates). Most infants (97%) were born at term. At or near term, maternal hemoglobin was significantly higher (+5.56 g/L) for iron vs. placebo groups. Anemia risk was reduced (RR: 0.53; 95% CI: 0.43, 0.66), as were risks of ID (RR: 0.74; 95% CI: 0.69, 0.79 by SF; RR: 0.65; 95% CI: 0.59, 0.71 by BI) and IDA (RR: 0.49; 95% CI: 0.38, 0.62 by SF; RR: 0.51; 95% CI: 0.40, 0.65 by BI). Most women still had ID (66.8% by SF, 54.7% by BI). Adverse effects, all minor, were similar by group. There were no differences in cord blood iron measures; >45% of neonates in each group had ID. However, dose-response analyses showed higher cord SF with more maternal iron capsules reported being consumed (β per 10 capsules = 2.60, P < 0.05).

conclusionsPrenatal iron supplementation reduced anemia, ID, and IDA in pregnant women in rural China, but most women and >45% of neonates had ID, regardless of supplementation. This trial was registered at clinicaltrials.gov as NCT02221752.

Indexed as

Dietary SupplementsRural PopulationAdultAnemia, Iron-DeficiencyChinaFemaleHumansInfant, NewbornIronIron DeficienciesMaternal Nutritional Physiological PhenomenaPregnancyYoung AdultIroniron deficiencyiron deficiency anemiairon supplementationneonatespregnant womenrandomized clinical trial

Identifiers

PMID26063068
PMCPMC4516762
OpenAlexW1951080534

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.