Evidence map›Paper›PMID 26062991›Full record

ArticleAtherosclerosis2015

Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice.

Chang Hyun Byon, Tieyan Han, Judy Wu, Simon T Hui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. N6-methyladenosine (miScience · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chang Hyun ByonDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Tieyan HanDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Judy WuDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Simon T HuiDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sthui@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Role of Txnip in adapting fuel metabolism to nutritional stateR01DK080339 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUI, SIMON TO-YUEN · 2009 to 2013
$1.7M
Role of Txnip in adapting fuel metabolism to nutritional stateR56DK080339 · NIDDK · SAN DIEGO STATE UNIVERSITY · PI HUI, SIMON TO-YUEN · 2008 to 2008
$150k
NIDDK NIH HHS DK080339NIDDK NIH HHS R01 DK080339NIDDK NIH HHS R56 DK080339
6 · The paper itself

Abstract

objectiveInflammation of vascular smooth muscle cells (VSMC) is intimately linked to atherosclerosis and other vascular inflammatory disease. Thioredoxin interacting protein (Txnip) is a key regulator of cellular sulfhydryl redox and a mediator of inflammasome activation. The goals of the present study were to examine the impact of Txnip ablation on inflammatory response to oxidative stress in VSMC and to determine the effect of Txnip ablation on atherosclerosis in vivo. METHODS AND

resultsUsing cultured VSMC, we showed that ablation of Txnip reduced cellular oxidative stress and increased protection from oxidative stress when challenged with oxidized phospholipids and hydrogen peroxide. Correspondingly, expression of inflammatory markers and adhesion molecules were diminished in both VSMC and macrophages from Txnip knockout mice. The blunted inflammatory response was associated with a decrease in NF-ĸB nuclear translocation. Loss of Txnip in VSMC also led to a dramatic reduction in macrophage adhesion to VSMC. In vivo data from Txnip-ApoE double knockout mice showed that Txnip ablation led to 49% reduction in atherosclerotic lesion in the aortic root and 71% reduction in the abdominal aorta, compared to control ApoE knockout mice.

conclusionOur data show that Txnip plays an important role in oxidative inflammatory response and atherosclerotic lesion development in mice. The atheroprotective effect of Txnip ablation implicates that modulation of Txnip expression may serve as a potential target for intervention of atherosclerosis and inflammatory vascular disease.

Indexed as

AnimalsAorta, AbdominalAortic DiseasesApolipoproteins EAtherosclerosisCarrier ProteinsCell AdhesionCell Adhesion MoleculesCells, CulturedCoculture TechniquesDisease Models, AnimalHydrogen PeroxideInflammationInflammation MediatorsMacrophagesMice, Inbred C57BLApolipoproteins ECarrier ProteinsCell Adhesion MoleculesHydrogen PeroxideInflammation MediatorsNF-kappa BThioredoxinsTxnip protein, mouseAtherosclerosisInflammationOxidative stress

Identifiers

PMID26062991
PMCPMC4509824
OpenAlexW1892228010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.