ArticleDevelopment (Cambridge, England)2015
JNK signalling is necessary for a Wnt- and stem cell-dependent regeneration programme.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.PLoS genetics · 2025Article
- Mining differentially expressed genes during paratomy in the transcriptome of the flatworm Stenostomum leucops.Scientific reports · 2024Article
- Article
- Injury-induced MAPK activation triggers body axis formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Src acts with WNT/FGFRL signaling to pattern the planarian anteroposterior axis.Development (Cambridge, England) · 2022Article
- A MEKK1 - JNK mitogen activated kinase (MAPK) cascade module is active in Echinococcus multilocularis stem cells.PLoS neglected tropical diseases · 2021Article
- Whole-Body Regeneration in the Lobate CtenophoreGenes · 2021Review
- STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling.Current biology : CB · 2020Article
- Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila: roles in cell competition, tumorigenesis and regeneration.Open biology · 2019Review
- Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa.BMC biology · 2019Article
- The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells.Developmental biology · 2018Article
- Wnt4 overexpression promotes thymoma development through a JNK-mediated planar cell polarity-like pathway.Oncology letters · 2018Article
- Effect of JNK inhibitor SP600125 on hair cell regeneration in zebrafish (Danio rerio) larvae.Oncotarget · 2016Article
- Article
- Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration.eLife · 2016Article
- Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form.Regeneration (Oxford, England) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Regeneration involves the integration of new and old tissues in the context of an adult life history. It is clear that the core conserved signalling pathways that orchestrate development also play central roles in regeneration, and further study of conserved signalling pathways is required. Here we have studied the role of the conserved JNK signalling cascade during planarian regeneration. Abrogation of JNK signalling by RNAi or pharmacological inhibition blocks posterior regeneration and animals fail to express posterior markers. While the early injury-induced expression of polarity markers is unaffected, the later stem cell-dependent phase of posterior Wnt expression is not established. This defect can be rescued by overactivation of the Hh or Wnt signalling pathway to promote posterior Wnt activity. Together, our data suggest that JNK signalling is required to establish stem cell-dependent Wnt expression after posterior injury. Given that Jun is known to be required in vertebrates for the expression of Wnt and Wnt target genes, we propose that this interaction may be conserved and is an instructive part of planarian posterior regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.