ArticleInternational journal of colorectal disease2015
How many segments are necessary to characterize delayed colonic transit time?
Article in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Sacral neuromodulation versus personalized conservative treatment in patients with idiopathic slow-transit constipation: study protocol of the No.2-trial, a multicenter open-label randomized controlled trial and cost-effectiveness analysis.International journal of colorectal disease · 2018Trial
- Relationship Between Colonic Transit Response to Eating With Self-reported Constipation Severity in Constipated Patients According to the Phenotype.Journal of neurogastroenterology and motility · 2024Article
- Degree of transverse colon ptosis: an alternative surrogate for evaluation of slow transit constipation.Quantitative imaging in medicine and surgery · 2023Article
- Biopsychosocial Model and Perceived Constipation Severity According to the Constipation Phenotype.Digestive diseases and sciences · 2021Article
- Clinical, Physiological, and Psychological Correlates of the Improvement of Defecation during Menses in Women with Functional Gastrointestinal Disorders.Visceral medicine · 2020Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Influence of Age and Body Mass Index on Total and Segmental Colonic Transit Times in Constipated Subjects.Journal of neurogastroenterology and motility · 2019Article
- More movement with evaluating colonic transit in humans.Neurogastroenterology and motility · 2019Review
- Painful or Mild-Pain Constipation? A Clinically Useful Alternative to Classification as Irritable Bowel Syndrome with Constipation Versus Functional Constipation.Digestive diseases and sciences · 2018Article
- Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders.Nature reviews. Gastroenterology & hepatology · 2018Review
- Colonic transit time and pressure based on Bernoulli's principle.Clinical and experimental gastroenterology · 2018Article
- Difficult defecation in constipated patients and its relationship to colonic disorders.International journal of colorectal disease · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMeasuring colonic transit time with radiopaque markers is simple, inexpensive, and very useful in constipated patients. Yet, the algorithm used to identify colonic segments is subjective, rather than founded on prior experimentation. The aim of the present study is to describe a rational way to determine the colonic partition in the measurement of colonic transit time.
methodsColonic transit time was measured in seven segments: ascending colon, hepatic flexure, right and left transverse colon, splenic flexure, descending colon, and rectosigmoid in 852 patients with functional bowel and anorectal disorders. An unsupervised algorithm for modeling Gaussian mixtures served to estimate the number of subgroups from this oversegmented colonic transit time. After that, we performed a k-means clustering that separated the observations into homogenous groups of patients according to their oversegmented colonic transit time.
resultsThe Gaussian mixture followed by the k-means clustering defined 4 populations of patients: "normal and fast transit" (n = 548) and three groups of patients with delayed colonic transit time "right delay" (n = 82) in which transit is delayed in the right part of the colon, "left delay" (n = 87) with transit delayed in the left part of colon and "outlet constipation" (n = 135) for patients with transit delayed in the terminal intestine. Only 3.7 % of patients were "erroneously" classified in the 4 groups recognized by clustering.
conclusionsThis unsupervised analysis of segmental colonic transit time shows that the classical division of the colon and the rectum into three segments is sufficient to characterize delayed segmental colonic transit time.
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