ArticleJournal of biomedical optics2015
En face Doppler total retinal blood flow measurement with 70 kHz spectral optical coherence tomography.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography.Scientific reports · 2019Trial
- Racial Variations in Retinal Oxygen Metabolic Biomarkers in Diabetic Retinopathy: A Pilot Study.Journal of ophthalmology · 2026Article
- Association of hemispheric retinal oxygen extraction and macular plexus-specific capillary density in moderate to advanced glaucomatous hemifield defect.Scientific reports · 2025Article
- Assessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager-A Pilot Study.Journal of clinical medicine · 2024Article
- Inner retinal oxygen delivery and metabolism in progressive stages of diabetic retinopathy.Scientific reports · 2024Article
- Variability of Retinal Oxygen Metrics in Healthy and Diabetic Subjects.Translational vision science & technology · 2021Article
- Repeatability and Reproducibility of Total Retinal Blood Flow Measurements Using Bi-Directional Doppler OCT.Translational vision science & technology · 2020Article
- Quantitative optical coherence tomography angiography: A review.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Waveform analysis of human retinal and choroidal blood flow with laser Doppler holography.Biomedical optics express · 2019Article
- Automated phase unwrapping in Doppler optical coherence tomography.Journal of biomedical optics · 2019Article
- Retinal Oxygen Delivery and Metabolism in Healthy and Sickle Cell Retinopathy Subjects.Investigative ophthalmology & visual science · 2018Article
- Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography.Translational vision science & technology · 2018Article
- Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography.The British journal of ophthalmology · 2018Article
- Spectroscopic Doppler analysis for visible-light optical coherence tomography.Journal of biomedical optics · 2017Article
- Glaucoma: the retina and beyond.Acta neuropathologica · 2016Review
- Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography.Investigative ophthalmology & visual science · 2016Article
- Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2016Review
- Detecting Blood Flow Response to Stimulation of the Human Eye.BioMed research international · 2015Review
- Is Spectral-Domain Optical Coherence Tomography Always Able to Detect the Anti-Vascular Endothelial Growth Factor Action on Neovascular Membrane?Case reports in ophthalmologyArticle
- Optical coherence tomography angiography: Technical principles and clinical applications in ophthalmology.Taiwan journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
An automated algorithm was developed for total retinal blood flow (TRBF) using 70-kHz spectral optical coherence tomography (OCT). The OCT was calibrated for the transformation from Doppler shift to speed based on a flow phantom. The TRBF scan pattern contained five repeated volume scans (2 x 2 mm) obtained in 3 s and centered on central retinal vessels in the optic disc. The TRBF was calculated using an en face Doppler technique. For each retinal vein, blood flow was measured at an optimal plane where the calculated flow was maximized. The TRBF was calculated by summing flow in all veins. The algorithm tracked vascular branching so that either root or branch veins are summed, but never both. The TRBF in five repeated volumes were averaged to reduce variation due to cardiac cycle pulsation. Finally, the TRBF was corrected for eye length variation. Twelve healthy eyes and 12 glaucomatous eyes were enrolled to test the algorithm. The TRBF was 45.4 ± 6.7 μl/min for healthy control and 34.7 ± 7.6 μl/min for glaucomatous participants (p-value = 0.01). The intravisit repeatability was 8.6% for healthy controls and 8.4% for glaucoma participants. The proposed automated method provided repeatable TRBF measurement.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.