ArticleMolecular medicine reports2015
Expression of HAX-1 in colorectal cancer and its role in cancer cell growth.
Article in Molecular medicine reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Biophysical and NMR analysis reveals binding affinity between HAX1 and CLPB proteins.Magnetic resonance letters · 2025Article
- Molecular functions of HAX1 during disease progress.Virus genes · 2024Review
- HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling.Stem cell reviews and reports · 2024Article
- The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.Nature communications · 2024Article
- The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.Cells · 2022Article
- Knockdown of Long Noncoding RNA 01124 Inhibits the Malignant Behaviors of Colon Cancer Cells via miR-654-5p/HAX-1.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.Journal of oncology · 2022Article
- miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.International journal of molecular sciences · 2021Review
- The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing.Bioscience reports · 2020Article
- Weighted gene coexpression network analysis identifies hub genes related to KRAS mutant lung adenocarcinoma.Medicine · 2020Article
- HAX-1 overexpression in gastric cancer promotes cell proliferation.Translational cancer research · 2020Article
- Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis.Journal of oncology · 2019Article
- Identification of the Functional Autophagy-Regulatory Domain in HCLS1-Associated Protein X-1 That Resists Against Oxidative Stress.DNA and cell biology · 2018Article
- Kostmann's Disease and HCLS1-Associated Protein X-1 (HAX1).Journal of clinical immunology · 2017Review
- Children with rare diseases of neutrophil granulocytes: from therapeutic orphans to pioneers of individualized medicine.Hematology. American Society of Hematology. Education Program · 2016Review
- Expression of HAX1 and Ki-67 in breast cancer and its correlations with patient's clinicopathological characteristics and prognosis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Hematopoietic cell‑specific protein 1‑associated protein X‑1 (HAX‑1) has been found to be involved in several types of cancer. However, the role of HAX‑1 in CRC remains to be elucidated. The aim of the present study was to investigate whether the expression of HAX‑1 is associated with the progression of CRC, and to determine the effects of HAX‑1 on the apoptosis and proliferation of CRC cells. Tumor tissues and adjacent noncancerous tissues were collected from 60 patients with CRC, following the provision of informed consent. The expression levels of HAX‑1 and the association with clinical and pathological characteristics were then analyzed. The expression levels of HAX‑1 were significantly higher in the cancerous tissues from the patients with CRC, particularly in tissues of an advanced stage of cancer. In addition, HAX‑1 expression was associated with malignant progression and poor prognosis. Furthermore, SW480 CRC cells, overexpressing HAX‑1, exhibited increased resistance to camptothecin in vitro, and promoted proliferation in vitro and in vivo. By contrast, HAX‑1 knockdown significantly decreased the proliferation. In addition, the expression levels of ki‑67 and phosphorylated‑akt were inhibited following HAX‑1 knockdown. In conclusion, the expression levels of HAX‑1 were increased in cancerous tissue from patients with CRC, and were associated with progression of the disease. These results suggested that HAX‑1 may contribute to chemotherapy resistance and malignant progression in CRC.
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