ArticlePloS one2015
Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Effects of different tooth sites and ages on the remodeling patterns of human mandibular alveolar bone.BMC oral health · 2026Article
- Perinatal vulnerability: its impact on oral and craniofacial hard tissue development.Frontiers in physiology · 2026Review
- Correlation analysis between occlusal plane and maxillofacial alterations in Chinese patients with an anterior disc displacement.BMC oral health · 2025Article
- Influence of bone morphogenetic protein (BMP) signaling and masticatory load on morphological alterations of the mouse mandible during postnatal development.Archives of oral biology · 2025Article
- The effects of dietary loading on the transdifferentiation of condylar chondrocytes.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2024Article
- The mandibular bone structure in children by fractal dimension and its correlation with pixel intensity values: a pilot study.Oral radiology · 2023Article
- The effects of anterior bite plane on temporomandibular joint and mandibular morphology.The Saudi dental journal · 2023Article
- The role of craniofacial maldevelopment in the modern OSA epidemic: a scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Effects of premature contact in maxillary alveolar bone in rats: relationship between experimental analyses and a micro scale FEA computational simulation study.Clinical oral investigations · 2021Article
- Microcracks on the Rat Root Surface Induced by Orthodontic Force, Crack Extension Simulation, and Proteomics Study.Annals of biomedical engineering · 2021Article
- Effect of inferior alveolar nerve transection on the inorganic component of bone of rat mandible.Journal of musculoskeletal & neuronal interactions · 2020Article
- Effects of Multi-Generational Soft Diet Consumption on Mouse Craniofacial Morphology.Frontiers in physiology · 2020Article
- Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions.Frontiers in endocrinology · 2020Review
- Forceful mastication activates osteocytes and builds a stout jawbone.Scientific reports · 2019Article
- Effects of gum chewing exercise on maximum bite force according to facial morphology.Clinical and experimental dental research · 2018Article
- Condylar Degradation from Decreased Occlusal Loading following Masticatory Muscle Atrophy.BioMed research international · 2018Article
- Variations in bone density across the body of the immature human mandible.Journal of anatomy · 2017Article
- A Novel Method to Detect 3D Mandibular Changes Related to Soft-Diet Feeding.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass. METHODS AND
findingsTen 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05).
conclusionDecreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
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