Evidence map›Paper›PMID 26061850›Full record

ArticleThe New England journal of medicine2015

Burden of Clostridium difficile infection in the United States.

Fernanda C Lessa, Lisa G Winston, L Clifford McDonald, Emerging Infections Program C. difficile Surveillance Team

Registry-linked trialAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The New England journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03030248 (Randomized Double Blind Controlled Trial for the Treatment of Nucleic Acid Amplification Test), which is not on this map. Cited by 195 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03030248 phase2completednot on this mapstarted 2018, after this paper: background citation

Randomized Double Blind Controlled Trial for the Treatment of Nucleic Acid Amplification Test (NAAT)+/Toxin Enzyme Immunoassay (EIA)- Clostridium Difficile in the Hematology Oncology Population

TypeinterventionalSponsorMedical College of WisconsinRan2018 to 2020Enrolled9ConditionsClostridium Difficile Infection, Hematologic Diseases, Bone Marrow Transplant, Oncologic DisordersArmsVancomycin Oral Capsule, Placebo Oral Capsule
3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Evaluation of the Cepheid Xpert C. difficile diagnostic assay: an update meta-analysis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021
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  5. Guideline
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  10. A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplant forCanadian journal of gastroenterology & hepatology · 2018
    Pooled it
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  15. Trial
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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Fernanda C Lessa
Lisa G Winston
L Clifford McDonald
Emerging Infections Program C. difficile Surveillance Team

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clostridioides difficileClostridium InfectionsFemaleHumansMale

Identifiers

PMID26061850
PMCPMC10880113

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.