Evidence map›Paper›PMID 26061726›Full record

ArticleEndocrinology2015

Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche.

Sheng Xia, Xiao-ping Li, Lu Cheng, Mu-tian Han, Miao-miao Zhang, Qi-xiang Shao, Hua-xi Xu, Ling Qi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
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  12. The initiation of metabolic inflammation in childhood obesity.The Journal of clinical investigation · 2017
    Review
  13. Lipid Inflammatory Mediators in Cancer Progression and Therapy.Advances in experimental medicine and biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Sheng XiaDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Xiao-ping LiDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Lu ChengDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Mu-tian HanDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Miao-miao ZhangDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Qi-xiang ShaoDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Hua-xi XuDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Ling QiDepartment of Immunology (S.X., M.Z., Q.S., H.X., L.Q.) and Institute of Clinic Laboratory Diagnosis (S.X., X.L., L.C., M.H., M.Z., Q.S., H.X.), School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China; and Division of Nutritional Sciences (S.X., L.Q.), Cornell University, Ithaca, New York 14853.
Jiangsu University · CN

Funding

Adipokine Signaling in MacrophagesR01DK082582 · NIDDK · CORNELL UNIVERSITY · PI QI, LING · 2009 to 2013
$1.6M
The Role of Sel1L and ER Quality Control in AdipocytesR01DK105393 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QI, LING · 2015 to 2018
$1.4M
NIDDK NIH HHS R01 DK082582NIDDK NIH HHS R01DK082582NIDDK NIH HHS R01 DK105393NIDDK NIH HHS R01DK105393
6 · The paper itself

Abstract

The self-renewal and differentiation of hematopoietic stem cells (HSCs) in bone marrow are essential to replenish all blood cell types, but how this process is influenced by diet remains largely unclear. Here we show that a diet rich in fish oils promotes self-renewal of HSCs and extramedullary hematopoiesis. Chronic intake of a fish oil-rich diet increases the abundance of HSCs, alters the hematopoietic microenvironment, and, intriguingly, induces the expression of matrix metalloproteinase 12 (MMP12) in the bone marrow. Pointing to a direct effect of fish oil on MMP12 expression, omega-3 polyunsaturated fatty acids induce the expression of MMP12 in a dose-dependent manner in bone marrow cells. Importantly, down-regulation of MMP12 activity using an MMP12-specific inhibitor attenuates diet-induced myelopoiesis in both bone marrow and spleen. Thus, a fish oil-rich diet promotes hematopoiesis in the bone marrow and spleen, in part via the activity of MMP12. Taken together, these data provide new insights into diet-mediated regulation of hematopoiesis.

Indexed as

DietAnimalsBone Marrow CellsCell ProliferationCells, CulturedFatty Acids, Omega-3Fish OilsHematopoiesisHematopoiesis, ExtramedullaryHematopoietic Stem CellsMaleMiceMice, Inbred C57BLSpleenStem Cell NicheFatty Acids, Omega-3Fish Oils

Identifiers

PMID26061726
PMCPMC4511132
OpenAlexW2189402106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.