Evidence map›Paper›PMID 26061701›Full record

ArticlePloS one2015

Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy.

Sana Waheed, Ahmad Sakr, Neha D Chheda, Gregory M Lucas, Michelle Estrella, Derek M Fine, Mohamed G Atta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guideline
  2. Pretransplant CD4 Count Influences Immune Reconstitution and Risk of Infectious Complications in Human Immunodeficiency Virus-Infected Kidney Allograft Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sana WaheedMedicine, University of Wisconsin School of Medicine, Madison, Wisconsin, United States of America.
Ahmad SakrAin Shams Faculty of Medicine, Cairo, Egypt.
Neha D ChhedaMedicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Gregory M LucasMedicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Michelle EstrellaMedicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Derek M FineMedicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Mohamed G AttaMedicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
Johns Hopkins University · USAin Shams University · EGJohns Hopkins Medicine · USUniversity of Wisconsin–Madison · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Bryan Lau · 2012 to 2026
$67.0M
VIRAL PATHOGENESIS OF HIV ASSOCIATED NEPHROPATHYP01DK056492 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KLOTMAN, PAUL EVAN · 1999 to 2021
$27.8M
Early-Stage Chronic Kidney Disease in HIV-infected IndividualsR01DA026770 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2010 to 2020
$5.7M
Treatment outcomes and comorbidity in HIV-infected IDUK24DA035684 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2014 to 2024
$1.5M
NIAID NIH HHS P30 AI094189NIDA NIH HHS K24 DA035684NIDA NIH HHS R01 DA026770NIDDK NIH HHS P01 DK056492NIDDK NIH HHS P01DK056492
6 · The paper itself

Abstract

introductionSeveral studies have demonstrated that renal transplantation in HIV positive patients is both safe and effective. However, none of these studies have specifically examined outcomes in patients with HIV-associated nephropathy (HIVAN).

methodsMedical records of all HIV-infected patients who underwent kidney transplantation at Johns Hopkins Hospital between September 2006 and January 2014 were reviewed. Data was collected to examine baseline characteristics and outcomes of transplant recipients with HIVAN defined pathologically as collapsing focal segmental glomerulosclerosis (FSGS) with tubulo-interstitial disease. RESULTS AND DISCUSSION: During the study period, a total of 16 patients with HIV infection underwent renal transplantation. Of those, 11 patients were identified to have biopsy-proven HIVAN as the primary cause of their end stage renal disease (ESRD) and were included in this study. They were predominantly African American males with a mean age of 47.6 years. Seven (64%) patients developed delayed graft function (DGF), and 6 (54%) patients required post-operative dialysis within one week of transplant. Graft survival rates at 1 and 3 years were 100% and 81%, respectively. Acute rejection rates at 1 and 3 years were 18% and 27%, respectively. During a mean follow up of 3.4 years, one patient died.

conclusionsAcute rejection rates in HIVAN patients in this study are higher than reported in the general ESRD population, which is similar to findings from prior studies of patients with HIV infection and ESRD of various causes. The high rejection rates appear to have no impact on short or intermediate term graft survival.

Indexed as

AdultAgedAIDS-Associated NephropathyDelayed Graft FunctionFemaleGraft RejectionHIV-1HumansKidney TransplantationMaleMiddle Aged

Identifiers

PMID26061701
PMCPMC4463848
OpenAlexW1580967446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.