ArticlePLoS neglected tropical diseases2015
Airborne Transmission of Melioidosis to Humans from Environmental Aerosols Contaminated with B. pseudomallei.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 79 citations in OpenAlex.
- SmartVax-Bp: An Immunoinformatic guided Multi-Epitope Vaccine Blueprint Against Burkholderia pseudomallei.Probiotics and antimicrobial proteins · 2026Article
- Dry Season Melioidosis in the Tropical North of Australia.Pathogens (Basel, Switzerland) · 2026Article
- Epidemiology, Clinical Features, and Outcomes of Chronic Melioidosis in the Top End of Australia's Northern Territory, 1989-2023.Open forum infectious diseases · 2026Article
- Hospital-Based Cross-Sectional Study ofGeoHealth · 2026Article
- Global dispersal of Burkholderia pseudomallei and the evolving endemicity of melioidosis in the United States of America.PLoS neglected tropical diseases · 2026Review
- Environmental Presence of Burkholderia pseudomallei at Military Sites in an Endemic Region: Implications for Future Deployments and Studies.The American journal of tropical medicine and hygiene · 2026Article
- Rainfall-Driven Mobilisation of Clinically RelevantPathogens (Basel, Switzerland) · 2026Article
- Geographical distribution of Burkholderia pseudomallei in Taiwanese croplands and the influence of bacterial community interactions on its incubation viability.PLoS neglected tropical diseases · 2025Article
- Spatial and Temporal Analyses of Melioidosis in Kaohsiung, Taiwan.The American journal of tropical medicine and hygiene · 2025Article
- Seasonal change of Burkholderia pseudomallei in paddy field water strongly correlates with ambient temperature: A study in north-central Vietnam.PLoS neglected tropical diseases · 2025Article
- Geographical and climatic contributions to melioidosis hotspot formation in Southern Taiwan.PLoS neglected tropical diseases · 2025Article
- Risk Assessment of Global Animal Melioidosis Under Current and Future Climate Scenarios.Animals : an open access journal from MDPI · 2025Article
- Genetic diversity, determinants, and dissemination of Burkholderia pseudomallei lineages implicated in melioidosis in Northeast Thailand.Nature communications · 2024Article
- AreHeliyon · 2024Article
- Epidemiology and genetic diversity of Burkholderia pseudomallei from Riau Province, Indonesia.PLoS neglected tropical diseases · 2024Article
- Burkholderia pseudomallei and melioidosis.Nature reviews. Microbiology · 2024Review
- [Characteristics and Diagnostic Tests of Melioidosis].Jugan geon-gang gwa jilbyeong · 2024Review
- A systematic review and meta-analysis of the global prevalence and relationships amongVeterinary world · 2024Article
- Genetic diversity, determinants, and dissemination ofbioRxiv : the preprint server for biology · 2023Article
- The effect of climate on melioidosis incidence in Townsville, Australia: a dry tropical region.Environmental health and preventive medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melioidosis results from an infection with the soil-borne pathogen Burkholderia pseudomallei, and cases of melioidosis usually cluster after rains or a typhoon. In an endemic area of Taiwan, B. pseudomallei is primarily geographically distributed in cropped fields in the northwest of this area, whereas melioidosis cases are distributed in a densely populated district in the southeast. We hypothesized that contaminated cropped fields generated aerosols contaminated with B. pseudomallei, which were carried by a northwesterly wind to the densely populated southeastern district. We collected soil and aerosol samples from a 72 km2 area of land, including the melioidosis-clustered area and its surroundings. Aerosols that contained B. pseudomallei-specific TTSS (type III secretion system) ORF2 DNA were well distributed in the endemic area but were rare in the surrounding areas during the rainy season. The concentration of this specific DNA in aerosols was positively correlated with the incidence of melioidosis and the appearance of a northwesterly wind. Moreover, the isolation rate in the superficial layers of the contaminated cropped field in the northwest was correlated with PCR positivity for aerosols collected from the southeast over a 2-year period. According to pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) analyses, PFGE Type Ia (ST58) was the predominant pattern linking the molecular association among soil, aerosol and human isolates. Thus, the airborne transmission of melioidosis moves from the contaminated soil to aerosols and/or to humans in this endemic area.
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