ArticlePloS one2015
Genotyping-By-Sequencing (GBS) Detects Genetic Structure and Confirms Behavioral QTL in Tame and Aggressive Foxes (Vulpes vulpes).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Identification of late blight resistance QTLsMolecular breeding : new strategies in plant improvement · 2025Article
- A cost-effective, high-throughput, highly accurate genotyping method for outbred populations.G3 (Bethesda, Md.) · 2025Article
- A Cost-effective, High-throughput, Highly Accurate Genotyping Method for Outbred Populations.bioRxiv : the preprint server for biology · 2024Article
- In Search of Species-Specific SNPs in a Non-Model Animal (European Bison (Animals : an open access journal from MDPI · 2021Article
- High diversity, inbreeding and a dynamic Pleistocene demographic history revealed by African buffalo genomes.Scientific reports · 2021Article
- Adapting Genotyping-by-Sequencing and Variant Calling for Heterogeneous Stock Rats.G3 (Bethesda, Md.) · 2020Article
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- Linkage Disequilibrium, Effective Population Size and Genomic Inbreeding Rates in American Mink Using Genotyping-by-Sequencing Data.Frontiers in genetics · 2020Article
- Genomic signatures of local adaptation to the degree of environmental predictability in rotifers.Scientific reports · 2018Article
- Reduced representation sequencing detects only subtle regional structure in a heavily exploited and rapidly recolonizing marine mammal species.Ecology and evolution · 2018Article
- Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.Nature ecology & evolution · 2018Article
- Population genomics and morphometric assignment of western honey bees (Apis mellifera L.) in the Republic of South Africa.BMC genomics · 2018Article
- Article
- Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes.G3 (Bethesda, Md.) · 2018Article
- Post-genomic behavioral genetics: From revolution to routine.Genes, brain, and behavior · 2018Review
- Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines.BMC genomics · 2018Article
- Ancestry informative alleles captured with reduced representation library sequencing in Theobroma cacao.PloS one · 2018Article
- Adapting Genotyping-by-Sequencing for Rice F2 Populations.G3 (Bethesda, Md.) · 2017Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
The silver fox (Vulpes vulpes) offers a novel model for studying the genetics of social behavior and animal domestication. Selection of foxes, separately, for tame and for aggressive behavior has yielded two strains with markedly different, genetically determined, behavioral phenotypes. Tame strain foxes are eager to establish human contact while foxes from the aggressive strain are aggressive and difficult to handle. These strains have been maintained as separate outbred lines for over 40 generations but their genetic structure has not been previously investigated. We applied a genotyping-by-sequencing (GBS) approach to provide insights into the genetic composition of these fox populations. Sequence analysis of EcoT22I genomic libraries of tame and aggressive foxes identified 48,294 high quality SNPs. Population structure analysis revealed genetic divergence between the two strains and more diversity in the aggressive strain than in the tame one. Significant differences in allele frequency between the strains were identified for 68 SNPs. Three of these SNPs were located on fox chromosome 14 within an interval of a previously identified behavioral QTL, further supporting the importance of this region for behavior. The GBS SNP data confirmed that significant genetic diversity has been preserved in both fox populations despite many years of selective breeding. Analysis of SNP allele frequencies in the two populations identified several regions of genetic divergence between the tame and aggressive foxes, some of which may represent targets of selection for behavior. The GBS protocol used in this study significantly expanded genomic resources for the fox, and can be adapted for SNP discovery and genotyping in other canid species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.