Evidence map›Paper›PMID 26061387›Full record

ArticleScientific reports2015

Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.

Mengyang Liu, Quan Pan, Yuanli Chen, Xiaoxiao Yang, Buchang Zhao, Lifu Jia, Yan Zhu, Boli Zhang, Xiumei Gao, Xiaoju Li and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  4. Experimental models in diabetes research.Laboratory animal research · 2026
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  20. Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice.The Yale journal of biology and medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mengyang Liu1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] College of Life Sciences, Nankai University, Tianjin 300071, China.
Quan Pan1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] College of Life Sciences, Nankai University, Tianjin 300071, China.
Yuanli Chen1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] Collaborative Innovation Center for Biotherapy, Nankai University, Tianjin 300071, China.
Xiaoxiao Yang1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] College of Life Sciences, Nankai University, Tianjin 300071, China.
Buchang ZhaoBuchang Pharmaceutical Co. Ltd., Xi'an 712000, China.
Lifu JiaBuchang Pharmaceutical Co. Ltd., Xi'an 712000, China.
Yan ZhuTianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Boli ZhangTianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Xiumei GaoTianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Xiaoju LiCollege of Life Sciences, Nankai University, Tianjin 300071, China.
Jihong Han1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] Collaborative Innovation Center for Biotherapy, Nankai University, Tianjin 300071, China.
Yajun Duan1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] Collaborative Innovation Center for Biotherapy, Nankai University, Tianjin 300071, China.
Nankai University · CNTianjin University of Traditional Chinese Medicine · CNBuchang Pharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Danhong Injection (DHI), a Chinese medicine for treatment of patients with coronary heart disease, inhibits primary abdominal aortic aneurysms in apoE deficient (apoE(-/-)) mice. Formation of microaneurysms plays an important role in the development of diabetic retinopathy and nephropathy. It remains unknown if DHI can reduce these diabetic complications. In this study, diabetic db/db mice in two groups were injected with saline and DHI, respectively, for 14 weeks. Blood and tissue samples were collected to determine serum glucose, lipids and tissue structure. DHI reduced diabetes-induced body weight gain, serum cholesterol and glucose levels. In retinas, DHI blocked the shrink of whole retina and retinal sub-layers by inhibiting expression of caspase 3, matrix metalloproteinase 2 (MMP-2) and MMP-9, accumulation of carbohydrate macromolecules and formation of acellular capillaries. DHI improved renal functions by inhibiting mesangial matrix expansion, expression of vascular endothelial growth factor A, fibronectin and advanced glycation end products in kidneys. Mechanistically, DHI induced expression of glucokinase, AMPKα/phosphorylated AMPKα, insulin receptor substrate 1, fibroblast growth factor 21 and peroxisome proliferator-activated γ. Expression of genes responsible for energy expenditure was also activated by DHI. Therefore, DHI inhibits diabetic retinopathy and nephropathy by ameliorating glucose metabolism and demonstrates a potential application in clinics.

Indexed as

AnimalsBiomarkersCaspase 3Caspase InhibitorsDiabetic NephropathiesDiabetic RetinopathyDisease Models, AnimalDrugs, Chinese HerbalEnergy MetabolismGlycation End Products, AdvancedMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMiceVascular Endothelial Growth Factor ABiomarkersCaspase 3Caspase InhibitorsdanhongDrugs, Chinese HerbalGlycation End Products, AdvancedMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsVascular Endothelial Growth Factor A

Identifiers

PMID26061387
PMCPMC4462147
OpenAlexW2272942851

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.