Evidence map›Paper›PMID 26061361›Full record

ArticleJournal of medicinal food2015

Artemisia asiatica Nakai Attenuates the Expression of Proinflammatory Mediators in Stimulated Macrophages Through Modulation of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways.

Eun-Kyung Kim, Yujiao Tang, Kwang-Suk Cha, Heeri Choi, Chun Bok Lee, Jin-Hwan Yoon, Sang Bae Kim, Jong-Shik Kim, Jong Moon Kim, Weon Cheol Han and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal food, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. A Chloroform Fraction Derived fromInternational journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Eun-Kyung Kim1 Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University , Chungju, Korea.
Yujiao Tang1 Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University , Chungju, Korea.
Kwang-Suk Cha3 Division of Sport Science, College of Science and Technology, Konkuk University , Chungju, Korea.
Heeri Choi3 Division of Sport Science, College of Science and Technology, Konkuk University , Chungju, Korea.
Chun Bok Lee4 Department of Korean Food and Culinary Arts, Youngsan University , Busan, Korea.
Jin-Hwan Yoon5 Institute for Natural Science Research, Hannam University , Daejeon, Korea.
Sang Bae Kim6 Division of Sports Science, Kangwon National University , Chuncheon, Korea.
Jong-Shik Kim7 Department of Sports Industry & Welfare, Wonkwang University , Jeonbuk, Korea.
Jong Moon Kim8 Department of Physical Medicine and Rehabilitation, Konkuk University Chungju Hospital , Chungbuk, Korea.
Weon Cheol Han9 Department Pathology, Sanbon Medical Center, Wonkwang University , Sanbon, Korea.
Suck-Jun Choi10 Department of Medical Non-Commissioned Officer, Wonkwang Health Science University , Jeonbuk, Korea.
Sangmin Lee11 Department of Industrial Engineering, Seoul National University , Seoul, Korea.
Eun-Ju Choi3 Division of Sport Science, College of Science and Technology, Konkuk University , Chungju, Korea.
Sang-Hyun Kim12 Laboratory of Immunotoxicology, Department of Pharmacology, School of Medicine, Kyungpook National University , Daegu, Korea.
Konkuk University · KRChungbuk National University Hospital · KRWonkwang University Hospital · KRHannam University · KRKangwon National University · KRKyungpook National University · KRSeoul National University · KRYoungsan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to examine the anti-inflammatory effects and potential mechanism of action of Artemisia asiatica Nakai (A. asiatica Nakai) extract in activated murine macrophages. A. asiatica Nakai extract showed dose-dependent suppression of lipopolysaccharide (LPS)-induced nitric oxide, inducible nitric oxide synthase, and cyclooxygenase-2 activity. It also showed dose-dependent inhibition of nuclear factor-κB (NF-κB) translocation from the cytosol to the nucleus and as an inhibitor of NF-κB-alpha phosphorylation. The extract's inhibitory effects were found to be mediated through NF-κB inhibition and phosphorylation of extracellular signal-regulated kinase 1/2 and p38 in LPS-stimulated J774A.1 murine macrophages, suggesting a potential mechanism for the anti-inflammatory activity of A. asiatica Nakai. To our knowledge, this is the first report of the anti-inflammatory effects of A. asiatica Nakai on J774A.1 murine macrophages; these results may help develop functional foods possessing an anti-inflammatory activity.

Indexed as

AnimalsAnti-Inflammatory AgentsArtemisiaCyclooxygenase 2LipopolysaccharidesMacrophagesMiceNF-kappa BNitric OxideNitric Oxide Synthase Type IIp38 Mitogen-Activated Protein KinasesPhosphorylationPlant ExtractsSignal TransductionAnti-Inflammatory AgentsCyclooxygenase 2LipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IIp38 Mitogen-Activated Protein KinasesPlant ExtractsArtemisia asiatica NakaiERK1/2NF-κBp38

Identifiers

PMID26061361
PMCPMC4523099
OpenAlexW1134767579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.