ArticleBehavioural pharmacology2015
Social stress during lactation, depressed maternal care, and neuropeptidergic gene expression.
Article in Behavioural pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Postpartum Depression Epidemiology, Risk Factors, Diagnosis, and Management: An Appraisal of the Current Knowledge and Future Perspectives.Journal of clinical medicine · 2025Review
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles.Nature communications · 2024Article
- Evaluation of Parameters Which Influence Voluntary Ingestion of Supplements in Rats.Animals : an open access journal from MDPI · 2023Article
- Oxytocin receptor gene methylation as a molecular marker for severity of depressive symptoms in affective disorder patients.BMC psychiatry · 2022Article
- Ethologically relevant repeated acute social stress induces maternal neglect in the lactating female mouse.Developmental psychobiology · 2021Article
- Regulatory Role of Orexin in the Antistress Effect of "Press Tack Needle" Acupuncture Treatment.Healthcare (Basel, Switzerland) · 2021Article
- Adaptations in reward-related behaviors and mesolimbic dopamine function during motherhood and the postpartum period.Frontiers in neuroendocrinology · 2020Review
- Neuroendocrine Effects of Lactation and Hormone-Gene-Environment Interactions.Molecular neurobiology · 2020Review
- Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression.Translational psychiatry · 2020Article
- Pathophysiological mechanisms implicated in postpartum depression.Frontiers in neuroendocrinology · 2019Review
- Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.Journal of affective disorders · 2018Article
- Prenatal Alcohol Exposure Is Associated With Adverse Cognitive Effects and Distinct Whole-Genome DNA Methylation Patterns in Primary School Children.Frontiers in behavioral neuroscience · 2018Article
- Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.Psychoneuroendocrinology · 2017Article
- Transgenerational Social Stress Alters Immune-Behavior Associations and the Response to Vaccination.Brain sciences · 2017Article
- Chronic social instability in adult female rats alters social behavior, maternal aggression and offspring development.Developmental psychobiology · 2017Article
- Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-γ and Behavior.Frontiers in endocrinology · 2016Article
- Transgenerational Social Stress, Immune Factors, Hormones, and Social Behavior.Frontiers in ecology and evolution · 2016Article
- Early life social stress induced changes in depression and anxiety associated neural pathways which are correlated with impaired maternal care.Neuropeptides · 2015Article
- Brain Reward Pathway Dysfunction in Maternal Depression and Addiction: A Present and Future Transgenerational Risk.Journal of reward deficiency syndromeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Depression and anxiety can be severely detrimental to the health of both the affected woman and her offspring. In a rodent model of postpartum depression and anxiety, chronic social stress exposure during lactation induces deficits in maternal care and increases anxiety. Here, we extend previous findings by expanding the behavioral analyses, assessing lactation, and examining several neural systems within amygdalar and hypothalamic regions involved in the control of the stress response and expression of maternal care that may be mediating the behavioral changes in stressed dams. Compared with control dams, those exposed to chronic social stress beginning on day 2 of lactation show impaired maternal care and lactation and increased maternal anxiety on day 9 of lactation. Saccharin-based anhedonia and maternal aggression were increased and lactation was also impaired on day 16 of lactation. These behavioral changes were correlated with a decrease in oxytocin mRNA expression in the medial amygdala, and increases in the expressions of corticotrophin-releasing hormone mRNA in the central nucleus of the amygdala, glucocorticoid receptor mRNA in the paraventricular nucleus, and orexin 2 receptor mRNA in the supraoptic nucleus of stressed compared with control dams. The increase in glucocorticoid receptor mRNA in the paraventricular nucleus was negatively correlated with methylation of a CpG site in the promoter region. In conclusion, the data support the hypothesis that social stress during lactation can have profound effects on maternal care, lactation, and anxiety, and that these behavioral effects are mediated by central changes in stress and maternally relevant neuropeptide systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.