Observational studyMedicine2015
Associations of Metabolic Syndrome and its Components With Mortality in the Elderly: A Cohort Study of 73,547 Taiwanese Adults.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association between metabolic syndrome and uric acid: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Pooled it
- Metabolic syndrome and spatial disparities: The role of socioeconomic deprivation and medical resource availability in the Cijin district, Taiwan.The Kaohsiung journal of medical sciences · 2024Article
- Clinical Management of Metabolic Syndrome Among the Population Attending Geriatric Outpatient Clinics in Qatar.Cureus · 2024Article
- The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms.Frontiers in pharmacology · 2024Review
- Burden of metabolic syndrome on primary healthcare costs among older adults: A cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- The prevalence and clustering of metabolic syndrome risk components in Chinese population: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Association of serum leptin with angiographically proven cardiovascular disease and with components of the metabolic syndrome: a cross-sectional study in East Azerbaijan.Cardiovascular endocrinology & metabolism · 2021Article
- Subtypes of Premorbid Metabolic Syndrome and Associated Clinical Outcomes in Older Adults.Frontiers in medicine · 2021Article
- New Simplified Diagnostic Decision Trees for the Detention of Metabolic Syndrome in the Elderly.International journal of environmental research and public health · 2020Article
- Article
- Thai CV Risk Score and Primary Prevention in Impaired Fasting Plasma Glucose or Diabetes Mellitus versus Normoglycemia in Patients with Metabolic Syndrome.International journal of preventive medicine · 2020Article
- Plasma lipid concentrations and survival in geriatric population: A retrospective cohort study.Medicine · 2019Observational
- Association between high-density lipoprotein cholesterol and all-cause mortality in the general population of northern China.Scientific reports · 2019Article
- Article
- Metabolic syndrome, its components and mortality: A population-based study.Medical journal of the Islamic Republic of Iran · 2019Article
- Metabolic Signature Differentiated Diabetes Mellitus from Lipid Disorder in Elderly Taiwanese.Journal of clinical medicine · 2018Article
- The effect of alpha-lipoic acid supplementation on anthropometric indices and food intake in patients who experienced stroke: A randomized, double-blind, placebo-controlled clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- The association between gallstone disease and plaque in the abdominopelvic arteries.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- The Relationship between Metabolically Obese Non-Obese Weight and Stroke: The Korea National Health and Nutrition Examination Survey.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Available evidence shows that metabolic syndrome (Mets) has clear adverse effects for middle-aged and pre-elderly adults; however, the effect of Mets on mortality among elderly adults remains unclear. In addition, the comparative utility of Mets and its component for predicting mortality among the elderly has not been clearly established. Using data from a large Taiwanese cohort, we evaluated the effect of Mets and its components on subsequent all-cause and cause-specific mortality overtime among the elderly. A total of 73,547 elders (age ≥65 years) participated in the Taipei Elderly Health Examination Program from 2007 to 2010. Mets was diagnosed using the adult treatment panel III criteria, and mortality was ascertained by using national death records. Time-dependent analysis was used to evaluate associations of Mets and its components with all-cause mortality, cardiovascular disease (CVD) mortality, and expanded CVD mortality. This retrospective cohort study found that 42.6% of elders had Mets. During 194,057 person-years of follow-up, 2944 deaths were observed. After adjusting for sociodemographic characteristics and comorbidities, Mets was associated with increased risk of expanded CVD mortality (hazard ratio [HR], 1.27; 95% CI, 1.10-1.46) but not all-cause or CVD mortality. Among Mets components, decreased high-density lipoprotein cholesterol (HDL-C, HR 1.25, 95% CI 1.13-1.37) and hyperglycemia (HR 1.21, 95% CI 1.12-1.31) were associated with a significant increase in all-cause mortality. Hypertension and low HDL-C were predictors of CVD mortality and expanded CVD mortality, and, as compared with Mets, were associated with a higher risk of expanded CVD mortality. The present findings indicate that, in elderly adults, individual components of Mets are better predictors of all-cause and cause-specific mortality than is Mets as a whole. Our results suggest that future efforts should focus on preventing and managing individual risk factors (particularly hypertension, low HDL-C, and hyperglycemia) rather than on "diagnosing" Mets in elders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.