Evidence map›Paper›PMID 26061317›Full record

Observational studyMedicine2015

Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease.

Kuang-Ming Liao, Chung-Han Ho, Shian-Chin Ko, Chung-Yi Li

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  8. Observational
  9. Article
  10. Biological sex and age-associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross-sectional study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Article
  11. Article
  12. Observational
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  14. Review
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  19. Article
  20. Perspectives on Cognitive Phenotypes and Models of Vascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kuang-Ming LiaoFrom the Department of Internal Medicine, Chi Mei Medical Center, Chiali (K-ML); Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University (K-ML); Department of Medical Research, Chi Mei Medical Center (C-HH); Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science (C-HH); Department of Chest Medicine, Chi Mei Medical Center (S-CK); Department of Public Health, College of Medicine, National Cheng Kung University, Tainan (C-YL); and Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan (C-YL).
Chung-Han Ho
Shian-Chin Ko
Chung-Yi Li
China Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disease in patients with chronic obstructive pulmonary disease (COPD) was observed. We aim to clarify the risk of dementia in patients with COPD. The study used claims data from Taiwan's National Health Insurance Research Database. Subjects were those who received a discharge diagnosis of COPD between January 1, 2002 and December 31, 2011. Only the first hospitalization was enrolled, and the index date was the first day of admission. Patients younger than 40 years or those with a history of Alzheimer disease (AD) or Parkinson disease (PD) before the index date were excluded. The patients with COPD were then followed until receiving a diagnosis of AD or PD, death, or the end of the study. Control subjects were selected from hospitalized patients without a history of COPD, AD, or PD and were matched according to age (±3 years), gender, and the year of admission at a 2:1 ratio. The comorbidities were measured from 1 year before the index date based on the ICD-9-CM codes. The study included 8640 patients with COPD and a mean age of 68.76 (±10.74) years. The adjusted hazard ratio of developing dementia (AD or PD) was 1.74 (95% confidence interval = 1.55-1.96) in patients with COPD compared with patients without COPD after adjusting for age, gender, and comorbidities. This nationwide cohort study demonstrates that the risk of dementia, including AD and PD, is significantly increased in patients with COPD compared with individuals in the general population.

Indexed as

AgedAlzheimer DiseaseCohort StudiesFemaleHumansMaleMiddle AgedParkinson DiseasePulmonary Disease, Chronic ObstructiveRetrospective StudiesRisk Assessment

Identifiers

PMID26061317
PMCPMC4616489
OpenAlexW2331660273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.