Evidence map›Paper›PMID 26061239›Full record

ArticleCurrent protocols in cell biology2015

In Vitro Analysis of the Very-Low Density Lipoprotein Export from the Trans-Golgi Network.

Shadab A Siddiqi

Abstract read
In one paragraph

Article in Current protocols in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Shadab A SiddiqiBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida.

Funding

A Cell Biological Approach to Hepatic Lipid MetabolismR01DK081413 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SIDDIQI, SHADAB A · 2008 to 2017
$2.7M
NIDDK NIH HHS R01 DK081413NIDDK NIH HHS R01 DK-81413
6 · The paper itself

Abstract

The movement of mature VLDL particles from the TGN to the plasma membrane (PM) is a complex physiological process that plays a critical role in hepatic lipid homeostasis. However, the molecular mechanisms regulating these intracellular transport events had not been studied until recently because of the lack of appropriate molecular assays and techniques. This unit provides a detailed description of cell-free approaches and techniques to study the TGN-to-PM transport of the mature VLDL at the molecular level. A major emphasis is placed on the preparation and purification of sub-cellular organelles because the success of in vitro assays for the vesicle formation and fusion depends on the quality of the isolated TGN, hepatic PM and hepatic cytosol. A number of critical factors that control the formation of mature VLDL-containing vesicle, the PG-VTV, from the TGN and their subsequent targeting to and fusion with the hepatic PM have been discussed.

Indexed as

AnimalsBiological TransportCell MembraneCytological TechniquesCytosolLipoproteins, VLDLMembrane FusionRats, Sprague-Dawleytrans-Golgi NetworkLipoproteins, VLDLapolipoprotein Bendoplasmic reticulum; triacylglycerolpost-golgi VLDL transport vesicle (PG-VTV)trans-Golgi network (TGN)very low-density lipoprotein (VLDL)

Identifiers

PMID26061239
PMCPMC4739700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.