Evidence map›Paper›PMID 26061015›Full record

SynthesisNutrients2015

Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis.

Chunla He, Zhoumeng Lin, Sara Wagner Robb, Amara E Ezeamama

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02803476 (Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?), which is not on this map. Cited by 104 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 11 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02803476 unknown statusnot on this mapstarted 2016, after this paper: background citation

Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?

TypeobservationalSponsorAin Shams Maternity HospitalRan2016 to 2016Enrolled166ConditionsPolycystic Ovary Syndrome, Insulin Resistance, Vitamin D Deficiency
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 11 syntheses or guidelines pooled it, 245 citations in OpenAlex.

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  5. Effects of vitamin D supplementation on oxidative stress biomarkers of Iranian women with polycystic ovary syndrome: a meta-analysis study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chunla HeDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 101 Buck Road, Health Sciences Campus, B.S. Miller Hall, Athens, GA 30602, USA. willahe@uga.edu.
Zhoumeng LinInstitute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. zhoumeng@ksu.edu.
Sara Wagner RobbDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 101 Buck Road, Health Sciences Campus, B.S. Miller Hall, Athens, GA 30602, USA. swagner@uga.edu.
Amara E EzeamamaDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 101 Buck Road, Health Sciences Campus, B.S. Miller Hall, Athens, GA 30602, USA. aezeamam@uga.edu.
University of Georgia · USKansas State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D deficiency (VDD) is common in women with and without polycystic ovary syndrome (PCOS) and may be associated with metabolic and endocrine disorders in PCOS. The aim of this meta-analysis is to assess the associations of serum vitamin D levels with metabolic and endocrine dysregulations in women with PCOS, and to determine effects of vitamin D supplementation on metabolic and hormonal functions in PCOS patients. The literature search was undertaken through five databases until 16 January 2015 for both observational and experimental studies concerning relationships between vitamin D and PCOS. A total of 366 citations were identified, of which 30 were selected (n = 3182). We found that lower serum vitamin D levels were related to metabolic and hormonal disorders in women with PCOS. Specifically, PCOS patients with VDD were more likely to have dysglycemia (e.g., increased levels of fasting glucose and homeostatic model assessment-insulin resistance index (HOMA-IR)) compared to those without VDD. This meta-analysis found no evidence that vitamin D supplementation reduced or mitigated metabolic and hormonal dysregulations in PCOS. VDD may be a comorbid manifestation of PCOS or a minor pathway in PCOS associated metabolic and hormonal dysregulation. Future prospective observational studies and randomized controlled trials with repeated VDD assessment and better characterization of PCOS disease severity at enrollment are needed to clarify whether VDD is a co-determinant of hormonal and metabolic dysregulations in PCOS, represents a consequence of hormonal and metabolic dysregulations in PCOS or both.

Indexed as

Blood GlucoseDatabases, FactualDietary SupplementsFemaleHumansInsulin ResistanceMetabolic SyndromeObservational Studies as TopicPolycystic Ovary SyndromeVitamin DBlood GlucoseVitamin Dmetabolic and endocrine disorderspolycystic ovary syndromesystematic review and meta-analysisvitamin D

Identifiers

PMID26061015
PMCPMC4488802
OpenAlexW1608070738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.