Evidence map›Paper›PMID 26060977›Full record

ArticleJAMA surgery2015

Thromboembolic Complications and Prophylaxis Patterns in Colorectal Surgery.

Colorectal Writing Group for Surgical Care and Outcomes Assessment Program–Comparative Effectiveness Research Translation Network (SCOAP-CERTAIN) Collaborative, Daniel W Nelson, Vlad V Simianu, Amir L Bastawrous, Richard P Billingham, Alessandro Fichera, Michael G Florence, Eric K Johnson, Morris G Johnson, Richard C Thirlby and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in JAMA surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05246943 (The Correlation of a D-dimer Testing Protocol With Venous Thromboembolism in Surgical Colorectal Patients), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05246943 withdrawnnot on this mapstarted 2022, after this paper: background citation

The Correlation of a D-dimer Testing Protocol With Venous Thromboembolism in Surgical Colorectal Patients

TypeobservationalSponsorThe University of Texas Medical Branch, GalvestonRan2022 to 2022Enrolled0ConditionsVenous Thromboses, Colorectal Cancer, Diverticular Diseases, Crohn DiseaseArmsD-dimer and lower limb venous duplex
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Are IBD Patients Underscored when Determining Postoperative VTE Risk?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
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  13. Time trends in the incidence rates of venous thromboembolism following colorectal resection by indication and operative technique.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Colorectal Writing Group for Surgical Care and Outcomes Assessment Program–Comparative Effectiveness Research Translation Network (SCOAP-CERTAIN) Collaborative
Daniel W NelsonMadigan Army Medical Center, Department of Surgery, Fort Lewis, Washington.
Vlad V SimianuUniversity of Washington, Department of Surgery, Seattle.
Amir L BastawrousSwedish Medical Center, Department of Surgery, Seattle, Washington.
Richard P BillinghamUniversity of Washington, Department of Surgery, Seattle.
Alessandro FicheraUniversity of Washington, Department of Surgery, Seattle.
Michael G FlorenceSwedish Medical Center, Department of Surgery, Seattle, Washington.
Eric K JohnsonMadigan Army Medical Center, Department of Surgery, Fort Lewis, Washington.
Morris G JohnsonSkagit Valley Medical Center, Department of Surgery, Mount Vernon, Washington.
Richard C ThirlbyVirginia Mason Medical Center, Department of Surgery, Seattle, Washington.
David R FlumUniversity of Washington, Department of Surgery, Seattle.
Scott R SteeleMadigan Army Medical Center, Department of Surgery, Fort Lewis, Washington.

Funding

Renewal: Gastrointestinal Surgery Outcomes Research FellowshipT32DK070555 · NIDDK · UNIVERSITY OF WASHINGTON · PI FLUM, DAVID R · 2010 to 2024
$3.6M
NIDDK NIH HHS T32 DK070555NIDDK NIH HHS T32DK070555
6 · The paper itself

Abstract

importanceVenous thromboembolism (VTE) is an important complication of colorectal surgery, but its incidence is unclear in the era of VTE prophylaxis.

objectiveTo describe the incidence of and risk factors associated with thromboembolic complications and contemporary VTE prophylaxis patterns following colorectal surgery. DESIGN, SETTING, AND

participantsProspective data from the Washington State Surgical Care and Outcomes Assessment Program (SCOAP) linked to a statewide hospital discharge database. At 52 Washington State SCOAP hospitals, participants included consecutive patients undergoing colorectal surgery between January 1, 2006, and December 31, 2011. MAIN OUTCOMES AND MEASURES: Venous thromboembolism complications in-hospital and up to 90 days after surgery.

resultsAmong 16,120 patients (mean age, 61.4 years; 54.5% female), the use of perioperative and in-hospital VTE chemoprophylaxis increased significantly from 31.6% to 86.4% and from 59.6% to 91.4%, respectively, by 2011 (P < .001 for trend for both). Overall, 10.6% (1399 of 13,230) were discharged on a chemoprophylaxis regimen. The incidence of VTE was 2.2% (360 of 16,120). Patients undergoing abdominal operations had higher rates of 90-day VTE compared with patients having pelvic operations (2.5% [246 of 9702] vs 1.8% [114 of 6413], P = .001). Those having an operation for cancer had a similar incidence of 90-day VTE compared with those having an operation for nonmalignant processes (2.1% [128 of 6213] vs 2.3% [232 of 9902], P = .24). On adjusted analysis, older age, nonelective surgery, history of VTE, and operations for inflammatory disease were associated with increased risk of 90-day VTE (P < .05 for all). There was no significant decrease in VTE over time. CONCLUSIONS AND RELEVANCE: Venous thromboembolism rates are low and largely unchanged despite increases in perioperative and postoperative prophylaxis. These data should be considered in developing future guidelines.

Indexed as

AgedAnticoagulantsChemopreventionColectomyColonDatabases, FactualDigestive System Surgical ProceduresFemaleHumansIncidenceIntestinal DiseasesMaleMiddle AgedRectumRisk FactorsVenous ThromboembolismAnticoagulants

Identifiers

PMID26060977
PMCPMC4545402

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.