ArticleJournal of renal injury prevention2015
Protective effect of pomegranate flower extract against gentamicin-induced renal toxicity in male rats.
Article in Journal of renal injury prevention, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Protective Effect of Moderate-Intensity Training and MgSoAdvanced biomedical research · 2026Article
- Exploring the Potential Role of Phytopharmaceuticals in Alleviating Toxicities of Chemotherapeutic Agents.Current protein & peptide science · 2024Review
- Effect of dietary pomegranate peel powder on productive traits, blood chemistry, economic efficiency and the expression of FSHR and LH-β genes in two strains of laying Japanese quail.Tropical animal health and production · 2021Article
- Eugenol Administration Improves Liver Damage Induced by a Fructose-Rich Diet.Advanced biomedical research · 2021Article
- Effects of Eugenol on Pain Response to the Formalin Test and Plasma Antioxidant Activity in High Fructose Drinking Water in Male Rats.International journal of preventive medicine · 2019Article
- Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.International journal of molecular sciences · 2018Review
- Sex Difference in Gentamicin-induced Nephrotoxicity: Influence of L-arginine in Rat Model.International journal of preventive medicine · 2018Article
- Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review.Journal of nephropathology · 2017Review
- Biochemical effects of oleuropein in gentamicin-induced nephrotoxicity in rats.ARYA atherosclerosis · 2016Article
- Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats.Scientifica · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGentamicin (GM) as an antibiotic is used in clinic. However, its administration is limited by side effects such as nephrotoxicity. Herbal extracts could be used in therapeutic approaches.
objectivesThe present study was planned to investigate whether pomegranate flower extract (PFE) could ameliorate GM-induced renal toxicity in male rats. MATERIALS AND
methodsTwenty eight male Wistar rats were divided into 5 groups. Groups 1 and 2 respectively received PFE 25 and 50 mg/kg for 9 days. Groups 3, 4 and 5 received saline, PFE 25 mg/kg, and PFE 50 mg/kg for 9 days, respectively, and GM (100 mg/kg/day) was administered from day 3 on. Blood samples were obtained, and after sacrificing the animals, the kidneys were removed for histopathology investigations.
resultsGM alone increased the serum levels of creatinine (Cr) and blood urea nitrogen (BUN), and tissue damage and kidney weight (P < 0.05). However, administration of low dose of PFE accompanied with GM decreased these markers significantly (P < 0.05). Low dose of PFE also ameliorated weight loss induced by GM (P < 0.05).
conclusionIt is concluded that PFE 25 mg/kg is the effective dose to ameliorate nephrotoxicity induced by GM.
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