ReviewJournal of stroke2015
A Functional Perspective on the Embryology and Anatomy of the Cerebral Blood Supply.
Review in Journal of stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
128 citing papers in PubMed, 3 syntheses or guidelines pooled it, 239 citations in OpenAlex.
- The anterior communicating artery variants: a meta-analysis with a proposed classification system.Surgical and radiologic anatomy : SRA · 2024Pooled it
- Congenital internal carotid artery hypoplasia: A systematic review.The neuroradiology journal · 2023Pooled it
- Anatomical variations in the Circle of Willis and the formation and rupture of intracranial aneurysms: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Human cerebral arterial morphogenesis explored by 3D microscopic imaging of cleared embryos: Bridging the gap between embryonic and adult anatomy.Journal of anatomy · 2026Article
- Intracranial Arterial Dolichoectasia in Spontaneous Intracerebral Hemorrhage: A Retrospective Cross-Sectional Study of Morphometric Features and Cerebral Small Vessel Disease.Journal of clinical medicine · 2026Article
- Alcohol Metabolism into Acetaldehyde in Developing Cerebral Arteries.International journal of molecular sciences · 2026Article
- Chronic Subdural Hematoma: Pathophysiology, Diagnosis, and the Emerging Role of Middle Meningeal Artery Embolization.Journal of clinical medicine · 2026Review
- Lack of Anterior Communicating Artery Is Associated with Symptomatic Middle Cerebral Artery Atherosclerosis.Biomedicines · 2026Article
- An Aberrant Internal Carotid Artery Mimicking a Pharyngeal Mass: A Rare Cause of Dysphagia.Clinical case reports · 2026Article
- Article
- Infarct Laterality Patterns in Relation to A1 Segment Hypoplasia/Aplasia According to Etiological Subtype.Brain sciences · 2026Article
- Right non-bifurcating cervical carotid artery with a long-segment incomplete carotid bifurcation, a right accessory middle cerebral artery arising from a common trunk with a cortical branch at the distal A1 segment.Surgical and radiologic anatomy : SRA · 2026Article
- Recurrent ischemic stroke caused by a carotid web: a case report.Journal of medical case reports · 2026Article
- The persistent proatlantal artery: types and subtypes.Surgical and radiologic anatomy : SRA · 2026Review
- An anatomical study of anterior spinal artery patterns in the Thai population.Surgical and radiologic anatomy : SRA · 2026Article
- Reframing moyamoya vasculopathy within steno-occlusive disease of the circle of Willis.Frontiers in stroke · 2026Review
- Prenatal Alcohol Exposure and Mitochondrial Function in the Brain.Advances in experimental medicine and biology · 2026Review
- Bilateral retropharyngeal course of the common, internal, and external carotid arteries: implications for neck dissection.Surgical and radiologic anatomy : SRA · 2025Article
- Ethanol Exposure Increases Oxygen Consumption by Developing Cerebral Arteries in a Trimester-, Concentration- and Sex-Dependent Manner.Biomolecules · 2025Article
- Imaging Characteristics of Persistent Carotid-Vertebrobasilar Anastomoses Detected by Ultrasound: A Case Series.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The anatomy of the arterial system supplying blood to the brain can influence the development of arterial disease such as aneurysms, dolichoectasia and atherosclerosis. As the arteries supplying blood to the brain develop during embryogenesis, variation in their anatomy may occur and this variation may influence the development of arterial disease. Angiogenesis, which occurs mainly by sprouting of parent arteries, is the first stage at which variations can occur. At day 24 of embryological life, the internal carotid artery is the first artery to form and it provides all the blood required by the primitive brain. As the occipital region, brain stem and cerebellum enlarge; the internal carotid supply becomes insufficient, triggering the development of the posterior circulation. At this stage, the posterior circulation consists of a primitive mesh of arterial networks that originate from projection of penetrators from the distal carotid artery and more proximally from carotid-vertebrobasilar anastomoses. These anastomoses regress when the basilar artery and the vertebral arteries become independent from the internal carotid artery, but their persistence is not uncommon in adults (e.g., persistent trigeminal artery). Other common remnants of embryological development include fenestration or duplication (most commonly of the basilar artery), hypoplasia (typically of the posterior communicating artery) or agenesis (typically of the anterior communicating artery). Learning more about the hemodynamic consequence that these variants may have on the brain territories they supply may help understand better the underlying physiopathology of cerebral arterial remodeling and stroke in patients with these variants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.