A Randomized, Controlled Trial of Levonorgestrel Vs. The Yuzpe Regimen as Emergency Contraception Method among Iranian Women.

Fatemeh Sadat Hoseini, Mohammad Eslami, Mohammed Abbasi, Fatemeh Noroozi Fashkhami, Soheila Besharati

Open access · greenAbstract read

In one paragraph

Article in Iranian journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed, 3 pooled it

–field-weighted citation impact, top 81% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 syntheses or guidelines pooled it, 5 citations in OpenAlex.

A Systematic Review and Meta-analysis of the Adverse Effects of Levonorgestrel Emergency Oral Contraceptive.Clinical drug investigation · 2020
Pooled it
Interventions for emergency contraception.The Cochrane database of systematic reviews · 2019
Pooled it
Interventions for emergency contraception.The Cochrane database of systematic reviews · 2017
Pooled it

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Fatemeh Sadat Hoseini1. Dept. of Anatomy, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran.

Mohammad Eslami2. Dept. of Population, Family and School Health, Ministry of Health and Medical Education , Tehran, Iran.

Mohammed Abbasi3. Family Planning Office, Gilan University of Medical Sciences , Rasht, Iran.

Fatemeh Noroozi Fashkhami3. Family Planning Office, Gilan University of Medical Sciences , Rasht, Iran.

Soheila Besharati3. Family Planning Office, Gilan University of Medical Sciences , Rasht, Iran.

Guilan University of Medical Sciences · IRMinistry of Health and Medical Education · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to compare acceptability of Levonorgestrel with the Yuzpe regimen among Iranian women based on their side-effects and resulting changes in the amount and pattern of menses.

methodsFive hundred twenty nine participants aged 15-49 having regular menses and one act of unprotected intercourse within 72 h were included in the double-blind, controlled trial in 2006-2007 and randomly assigned into LNG (n=263) and HD (n=266) groups, receiving Levonorgestrel 0.75 mg given 12 h apart and ethinyl estradiol 100 μg plus 0.5 mg Levonorgestrel 0.5 mg repeated after 12 h, respectively.

resultsThe participants receiving Levonorgestrel experienced significantly lower side-effects in the case of nausea, vomiting, and dizziness (P<0.05). The changes occurred in the amount and pattern of menses were the same for both groups (P>0.05). No significant difference was observed between the efficiencies of the treatments.

conclusionSignificantly lower side-effects of Levonorgestrel can be considered as greater acceptability and translated to higher efficiency.

Indexed as

Emergency contraceptionLevonorgestrelSide-effectsYuzpe regimen

Identifiers

PMID26060625

PMCPMC4436545

OpenAlexW2169654203

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.