ArticleNutrition research and practice2015
Inhibitory effects of Doenjang, Korean traditional fermented soybean paste, on oxidative stress and inflammation in adipose tissue of mice fed a high-fat diet.
Article in Nutrition research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Fermented Fruits, Vegetables, and Legumes in Metabolic Syndrome: From Traditional Use to Functional Foods and Medical Applications.Nutrients · 2025Review
- Evaluation of antiobesogenic properties of fermented foods: In silico insights.Journal of food science · 2025Review
- Article
- Article
- Significance of Soy-Based Fermented Food and Their Bioactive Compounds Against Obesity, Diabetes, and Cardiovascular Diseases.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Review
- Antiobesity effect of healthy food crops and functional foods: A systematic review of their mechanisms.Food science & nutrition · 2024Review
- Article
- In Vitro Antibacterial Effect of the Methanolic Extract of the Korean Soybean Fermented Product Doenjang againstAnimals : an open access journal from MDPI · 2021Article
- Effects of the Addition of Herbs on the Properties of Doenjang.Foods (Basel, Switzerland) · 2021Article
- Diet-induced obesity in animal models: points to consider and influence on metabolic markers.Diabetology & metabolic syndrome · 2021Review
- Antioxidant Activity of Sprouts Extracts Is Correlated with Their Anti-Obesity and Anti-Inflammatory Effects in High-Fat Diet-Fed Mice.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Anti-obesity and anti-inflammatory effects of ginseng vinegar in high-fat diet fed mice.Food science and biotechnology · 2019Article
- Effects of Doenjang, a Traditional Korean Soybean Paste, with High-Salt Diet on Blood Pressure in Sprague-Dawley Rats.Nutrients · 2019Article
- Article
- Effects of Resistance Exercise and Fermented Soybean Consumption on Glucose Tolerance and Expressions of Immune Senescence-Related Myokines in Middle-Aged Obese Rats.Journal of obesity & metabolic syndrome · 2018Article
- Effect of Drying Conditions on Nutritional Quality andPreventive nutrition and food science · 2018Article
- Antioxidant and Neuroprotective Effects ofPreventive nutrition and food science · 2016Article
- Anti-inflammatory and anti-diabetic effects of brown seaweeds in high-fat diet-induced obese mice.Nutrition research and practice · 2016Article
- Kimchi and Other Widely Consumed Traditional Fermented Foods of Korea: A Review.Frontiers in microbiology · 2016Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesDoenjang, Korean traditional fermented soybean paste has been reported to have an anti-obesity effect. Because adipose tissue is considered a major source of inflammatory signals, we investigated the protective effects of Doenjang and steamed soybean on oxidative stress and inflammation in adipose tissue of diet-induced obese mice. MATERIALS/
methodsMale C57BL/6J mice were fed a low fat diet (LF), a high-fat diet (HF), or a high-fat containing Doenjang diet (DJ) or a high-fat containing steamed soybean diet (SS) for 11 weeks.
resultsMice fed a DJ diet showed significantly lower body and adipose tissue weights than those in the HF group. Although no significant differences in adipocyte size and number were observed among the HF diet-fed groups, consumption of Doenjang alleviated the incidence of crown-like structures in adipose tissue. Consistently, we observed significantly reduced mRNA levels of oxidative stress markers (heme oxygenase-1 and p40(phox)), pro-inflammatory adipokines (tumor necrosis factor alpha and macrophage chemoattractant protein-1), macrophage markers (CD68 and CD11c), and a fibrosis marker (transforming growth factor beta 1) by Doenjang consumption. Gene expression of anti-inflammatory adipokine, adiponectin was significantly induced in the DJ group and the SS group compared to the HF group. The anti-oxidative stress and anti-inflammatory effects observed in mice fed an SS diet were not as effective as those in mice fed a DJ diet, suggesting that the bioactive compounds produced during fermentation and aging may be involved in the observed health-beneficial effects of Doenjang.
conclusionsDoenjang alleviated oxidative stress and restored the dysregulated expression of adipokine genes caused by excess adiposity. Therefore, Doenjang may ameliorate systemic inflammation and oxidative stress in obesity via inhibition of inflammatory signals of adipose tissue.
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